"This respected reference combines comprehensive authoritative coverage with practical clinical guidance in a clearly organized and highly visual format. Hundreds of international experts offer how-to advice for the evaluation and diagnosis of a full range of musculoskeletal conditions…proven approaches to medical and surgical treatment…strategies for rehabilitation and outcome assessment…the latest pain management techniques…and much more. The 3rd Edition features increased coverage of evidence-based practice non-drug therapy bone disorders management of pediatric and geriatric patients clinical assessment and outcomes evaluation and the fully searchable website lets practitioners put today’s technology into their practice! "

"VOLUME ONE SECTION I: INTRODUCTION TO THE STUDY OF RHEUMATIC DISEASES 1. History of rheumatic diseases 2. Classification of rheumatic diseases 3. Epidemiologic concepts and rheumatology 4. Principles of outcome assessment 5. The worldwide economic and functional impact of rheumatic disease 6. The provision of rheumatologic services 7. Principles of health-economics and application to rheumatic disorders SECTION II: THE SCIENTIFIC BASIS OF RHEUMATIC DISEASE 8. The musculoskeletal system 9. Joint physiology 10. Biomechanics 11. Principles and techniques of molecular biology 12. Genetic factors in rheumatic disease 13. Principles of Immunology 14. Tissue destruction and repair 15. Neuropeptides and free radicals 16. Inflammation 17. The synovium SECTION III: EVALUATION SIGNS AND SYMPTOMS 18. History and physical Examination 19. Pattern Recognition Arthritis 20. Laboratory tests in rheumatic disorders 21. Testing for ANA and ANCA - Diagnostic value and pitfalls 22. Synovial fluid analysis 23. Aspiration and injection of joints and periarticular tissues 24. Minimally invasive procedures 25. Imaging principles and techniques 26. Skin and rheumatic disease 27. The eye and rheumatic disease 28. The heart in rheumatic disease 29. The lung in rheumatic disease 30. Gastrointestinal tract and rheumatic disease 31. The kidney and rheumatic disease SECTION IV: PRINCIPLES OF MANAGEMENT 32. Principles of management of patients with rheumatic disease 33. Health promotion and patient education for People with arthritis 34. Principles of pain and pain management 35. NSAIDs 36. Systemic corticosteroids in rheumatology 37. Intra-articular and intralesional therapy 38. DMARDS 1 Antimalarials and gold d-penicillamine 39. DMARDS 2 (sulfasalazine dapsone) 40. DMARDS 3 (methotrexate) 41. DMARDS 41 (leflunomide) 42. Immunosuppressives (chlorambucil cyclosporin cytoxan imuran mofetil tacrolimus) 43. Immunotherapies Tcell Bcell complement 44. Thalidomide 45. Cytokine neutralizers 46. Emerging therapeutic targets 47. Antibiotics 48. Drugs and Pregnancy 49. Alternative and complementary medicine 50. Principles of rehabilitation 51. Principles of arthritis surgery SECTION V: REGIONAL AND WIDESPREAD PAIN 52. Anatomy and biomechanics of the spine 53. Neck pain 54. Low back pain and lumbar spinal stenosis 55. The shoulder 56. The elbow 57. The wrist and hand 58. The hip 59. The knee 60. The ankle and foot 61. Temporomandibular pain syndrome 62. Fibromyalgia and related syndromea 63. Entrapment neuropathies and compartment syndromes 64. Algodystrophy/reflex sympathetic dystrophy syndrome 65. Sports medicine: the clinical spectrum of injury SECTION VI: RHEUMATOID ARTHRITIS AND OTHER SYNOVIAL DISORDERS 66. History 67. Classification and epidemiology 68. Clinical features of rheumatoid arthritis 69. Extrarticular features of rheumatoid arthritis and systemic involvement 70. Adult Still’s disease 71. Imaging of rheumatoid arthritis 72. Genetics of the major histocompatibility complex in rheumatoid arthritis 73. Animal models of arthritis 74. Autoantibodies in rheumatoid arthritis 75. Cellular immunity in rheumatoid arthritis 76. Angiogenesis in rheumatoid arthritis 77. Rheumatoid synovitis and pannus 78. Evaluation and management of early I nflammatory polyarthritis 79. Evaluation and outcome of the patient with established rheumatoid arthritis 80. Management of rheumatoid arthritis: synovitis 81. Management of extra-articular disease and complications 82. Multidisciplinary approach to rheumatoid arthritis SECTION VII: PEDIATRIC RHEUMATOLOGY 83. History 84. Classification and epidemiology of juvenile inflammatory arthritis 85. Clinical features and special problems and presentations in children 86. Evaluation of muskuloskeletal complaints in children 87. Legg–Perthes and other hip diseases in children 88. Etiology and pathogenesis JCA 89. JRA Management 90. Connective tissue diseases in children 91. Rehabilitation and psychosocial issues VOLUME TWO SECTION VIII: INFECTION-RELATED RHEUMATIC DISEASES INFECTION 92. Microorganisms and the locomotor system 93. Septic arthirits and osteomyelitis 94. Gonococcal arthritis 95. Mycobacterial brucella fungal and parasitic arthritis 96. Lyme disease and syphilitic arthritis 97. Viral arthritis 98. Rheumatic aspects of human immunodeficiency virus infection and other immunodeficient states 99. Acute rheumatic fever SECTION IX: SPONDYLOARTHROPATHIES 100. History 101. Classification of spondyloarthropathy 102. Epidemiology of ankylosing spondylitis 103. Clinical features of ankylosing spondylitis 104. Etiology and pathogenesis of ankylosing spondylitis 105. Ankylosing spondylitis: Imaging 106. Ankylosing spondylitis: pathology 107. Ankylosing spondylitis: management 108. Reactive arthritis: etiology and pathogenesis 109. Reactive arthritis: clinical features and treatment 110. Psoriatic arthritis: clinical features 111. Psoriatic arthritis: etiology and pathogenesis 112. Psoriatic arthritis: management 113. Enteropathic arthropathies – diagnosis and treatment 114. Enthesopathy SECTION X: CONNECTIVE TISSUE DISORDERS SYSTEMIC LUPUS ERYTHEMATOSUS 115. History 116. Epidemiology and classification of SLE 117. Immunopathology 118. Genetics of lupus 119. The complement system 120. Autoantibodies in SLE 121. Cellular immunology 122. Clinical features 123. Neonatal lupus 124. Drug-induced lupus 125. Assessing disease activity and outcome in SLE 126. Treatment – skin joints serositis pneumonitis constitutional etc 127. Treatment – renal involvement 128. Severe SLE 129. Pregnancy in SLE 130. Sjögren s syndrome 131. Antiphospholipid syndrome: diagnosis and management SYSTEMIC SCLEROSIS 132. History of epidemiology and outcome measurements of scleroderma 133. Clinical features 134. Etiology and pathogenesis 135. Management 136. Raynaud s phenomenon 137. Localized scleroderma and idiopathic and environmentally induced scleroderma variants INFLAMMATORY MUSCLE DISEASE 138. Etiology and pathogenesis 139. Clinical features of inflammatory disease 140. Management of Inflammatory Muscle Disease 141. Inflammatory and metabolic myopathies 142. Overlap syndromes SECTION XI: THE VASCULITIDES 143. Overview of the inflammatory vascular diseases 144. Biology of the vascular endothelium 145. Immunopathogenesis of vasculitis 146. Polyarteritis – polyarteritis nodosa and microscopic polyangiitis 147. Polymyalgia rheumatica and giant cell arthritis 148. Wegener s granulomatosis and lymphomatoid granulomatosis 149. Churg–Strauss syndrome 150. Takayasu s arteritis 151. Behçet s syndrome 152. Kawasaki disease 153. Henoch–Schönlein purpura 154. Panniculitis 155. Cutaneous vasculitis 156. Cryoglobulinemia 157. Primary angiitis of the central nervous system SECTION XII: OTHER SYSTEMIC ILLNESSES 158. Familial Mediterranean fever 159. Sarcoidosis 160. Relapsing polychondritis 161. Miscellaneous arthropathies including synovial tumors and foreign body synovitis 162. Hypertrophic osteoarthropathy 163. Cogan’s Syndrome SECTION XIII: OSTEOARTHRITIS AND RELATED DISORDERS OSTEOARTHRITIS AND RELATED DISORDERS 164. Epidemiology and classification 165. Clinical features 166. Osteoarthritis: pathogenesis 167. The genetics of osteoarthritis 168. Imaging 169. Pathology 170. Evaluation of the patient with osteoarthritis and measurement of outcomes 171. Management of limb joint osteoarthritis 172. Diffuse idiopathic skeletal hyperostosis 173. Neuropathic arthropathy 174. Osteonecrosis SECTION XIV: CRYSTAL-RELATED ARTHROPATHIES 175. Epidemiology classification and history of crystal-related arthropathies 176. Etiology and pathogenesis of gout 177. Clinical features of gout 178. The management of gout 179. Calcium pyrophosphate dihydrate – crystal deposition disease (pseudogout) 180. Basic calcium phosphate crystal deposition disease 181. Other crystal associated arthropathies SECTION XV: ENDOCRINE AND HEMOGLOBIN-RELATED ARTHRITIS AND STORAGE DISEASES 182. Acromegaly 183. Rheumatologic manifestations of thyroid diseases 184. Diabetes mellitus 185. Dialysis arthropathy 186. Primary hyperlipidemias and xanthomatosis 187. Hemophilia and other bleeding disorders 188. Joint and bone lesions in hemoglobinopathies 189. Hemochromatosis 190. Ochronosis 191. The amyloidoses SECTION XVI: METABOLIC BONE DISEASES 192. Bone structure and function 193. Investigations of bone: biochemical markers 194. Epidemiology classification and history of Osteoporosis 195. Investigations of bone: imaging 196. Osteoporosis: pathogenesis 197. Osteoporosis: clinical features 198. Management of osteoporosis 199. Glucocorticoid-induced osteoporosis 200. Rickets and osteomalacia 201. Hyperparathyroidism 202. Renal bone disease 203. Paget s disease of bone SECTION XVII: HEREDITABLE DISEASE AND TUMORS OF BONE AND CONNECTIVE TISSUE 204. Gaucher s disease 205. Mucopolysaccharidoses 206. Heritable collagen disorders 207. Hypermobility syndrome 208. Skeletal Dysplasias 209. Tumors of bone "

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