"This book is an invaluable resource that provides an overview of all aspects of the care of patients with haemophilia. Covering how to assess both bleeding children and adults Haemophilia A and B molecular basis of the disease the role of factors in coagulation epidemiology pharmacokinetics and treatment of inhibitors. There will also be a section on musculoskeletal aspects of haemophilia as well as newer developments such as gene therapy and rare bleeding disorders. "

"Part I: Introduction 1 Overview of Hemostasis 2 Cellular Processing of Factor VIII and IX 3 Work-up of a Bleeding Adult Part II: HEMOPHILIA A 4 Molecular Basis of Hemophilia A 5 Hemophilia A: Role of Factor VIII in Coagulation 6 Natural History of Inhibitor Development in Children with Severe Hemophilia A Treated with Factor VIII Products 7 Prophylaxis 8 Continuous Infusion of Coagulation Products in Hemophilia Part III: Inhibitors to Factor VIII 9 Inhibitors to Factor VIII - Immunology 10 Inhibitors to Factor VIII - Molecular Basis 11 Inhibitors to Factor VIII - Epidemiology and Treatment 12 Inhibitors to Factor VIII - Mid and Moderate Hemophilia 13 Inhibitors to Factor VIII/IX: Treatment of Inhibitors - Immune Tolerance Induction 14 Inhibitors of Factor VIII: Treatment of Acute Bleeds Part IV: Acquired Hemophilia 15 Acquired Inhibitors to Factor VIII Part V: Hemophilia B 16 Hemophilia B - Molecular Basis 17 Inhibitors in Hemophilia B 18 Treatment Inhibitors in Hemophilia B Part VI: Pharmacokinetics of Factors VIII & IX 19 Pharmacokinetics Part VII: Pediatrics 20 Work-up of a Bleeding Child 21 Care of the Child with Hemophilia 22 To Neonate with Hemophilia Part VIII: Products Used to Treat Hemophilia 23 Products Used to Treat Hemophilia: Evolution of Treatment for Hemophilia A and B 24 Products Used to Treat Hemophilia: Recombinant Products 25 Products Used to Treat Hemophilia: Plasma-Derived Coagulation Factor Concentrates 26 Products Used to Treat Hemophilia: Recombinant Factor VIIa 27 Products Used to Treat Hemophilia: Dosing 28 Products Used to Treat Hemophilia: Regulation Part IX: Muscoskeletal 29 Joint Replacement 30 Synovioarthesis in Hemophilia 31 Pseudotumours in patients with Hemophilia 32 Radiology 33 Magnetic Resonance Imaging/ Joint Outcome 34 Physiotherapy in the Management of Hemophilia Part X: Transfusion-Transmitted Disease 35 Transfusion Transmitted Disease: History of Epidemics (Focus on HIV) 36 Transfusion Transmitted Disease: Hepatitis C Virus Infection and Liver Transplantation Part XI: Gene Therapy 37 Gene Therapy: Introduction and Overview 38 Gene Therapy for Hemophilia B 39 Gene Therapy for Hemophilia A 40 Gene Therapy: Molecular Engineering of Factor VIII and Factor IX Part XII: Laboratory 41 Laboratory Assays in Hemophilia 42 Standardization of Assays Part XIII: Obstetrics & Gynaecology 43 Obstetrics and Gynecology: Hemophilia Part XIV: Von Willebrand Disease 44 von Willebrand Disease: Molecular Aspects 45 von Willebrand Disease: Epidemiology 46 von Willebrand Disease: Biological Diagnosis 47Classification and Clinical Aspects of von Willebrand Disease Part XV: Treatment of Von Willebrand Disease 48 Treatment of von Willebrand Disease: Desmopressin 49 Treatment of von Willebrand Disease: Therapeutic Concentrates 50 Women & Von Willebrand Disease Part XVI: Rare Bleeding Disorders 51 Factor II 52 Factor V and combined Factor V and VIII Deficiencies 53 Congenital Factor VII Deficiency 54 Factor X and Factor X Deficiency 55 Factor XI Deficiency 56 Factor XIII 57 Fibrinogen 58 Miscellaneous Rare Bleeding Disorders XVII: Quality of Life 59 Quality of Life in Hemophilia XVIII: Economics 60 The Economics of Hemophilia Treatments XIX: Comprehensive Care and Delivery of Care 61 Comprehensive Care and Delivery of Care: The Developed World 62 The Comprehensive Care and Delivery of Care: The Developing World 63 Comprehensive Care and Delivery of Care: The Global Perspective Index "

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