Oral-based diagnostics have the potential to detect systemic disease and evidence of exposure to various harmful substances, as well as provide biomarkers of health and disease status. Integration of novel approaches to oral-based diagnostics is expanding to include genomics, proteomics, bioinformatics, and nanotechnology.

Improved technologies for diagnostics are resulting in more "user-friendly" methods. Efforts to translate bench assays to commercial products in the area of oral diagnostics have increased recently, as witnessed by the appearance of several new oral-based diagnostic products in the marketplace. Collaborative academic, government, and industry relationships in this arena are also forming, all of which will undoubtedly serve to rapidly advance the field.

This volume brings together contributions from leaders in the areas of toxicology, pathology, oral biology, dental research, and clinical medicine.

Dedication to Irwin Mandel: Daniel Malamud Introduction: Daniel Malamud and R. Sam Niedbala Part I: Biochemistry/Physiology of Saliva: Implications for Diagnostics: 1. Implications for Diagnostics in the Biochemistry and Physiology of Saliva: Arie V. Nieuw Amerongen, Antoon J. M. Ligtenberg, and Enno C. I. Veerman 2. Point-of-Care Diagnostics Enter the Mouth: Lawrence A. Tabak 3. Autoimmune Diseases and Sjögren's Syndrome: An Autoimmune Exocrinopathy: Philip C. Fox 4. Salivary Proteome and Its Genetic Polymorphisms: Frank G. Oppenheim, Erdjan Salih, Walter L. Siqueira, Weimin Zhang, and Eva J. Helmerhorst Part II: Drug and Small Molecule Detection in Saliva: 5. Interpretation of Oral Fluid Tests for Drugs of Abuse: Edward J. Cone and Marilyn A. Huestis 6. Methamphetamine Disposition in Oral Fluid, Plasma, and Urine: Marilyn A. Huestis and Edward J. Cone 7. Salivary α-Amylase in Biobehavioral Research: Recent Developments and Applications: Douglas A. Granger, Katie T. Kivlighan, Mona El-Sheikh, Elena Gordis, and Laura R. Stroud 8. The Use of Oral Fluid for Therapeutic Drug Management: Clinical and Forensic Toxicology: Loralie J. Langman Part III: Meeting Unmet Needs in Diagnostics: 9. Visualization and Other Emerging Technologies as Change Makers for Oral Cancer Prevention: Miriam P. Rosin, Catherine F. Poh, Martial Guillard, P. Michele Williams, Lewei Zhang, and Calum Macaulay 10. Genomic Targets in Saliva: Bernhard G. Zimmermann, Noh Jin Park, and David T. Wong 11. Saliva and the Clinical Pathology Laboratory: Michael A. Pesce and Steven L. Spitalnik Part IV: Oral Samples/Oral Diseases: 12. Oral Diseases: From Detection to Diagnostics: Antoon J. M. Ligtenberg, Johannes J. De Soet, Enno C. I. Veerman, and Arie V. Nieuw Amerongen 13. A Novel Caries Risk Test: Paul C. Denny, Patricia A. Denny, Jona Takashima, Joyce Galligan, and Mahvash Navazesh 14. Analysis of Gingival Crevicular Fluid as Applied to the Diagnosis of Oral and Systemic Diseases: Ira B. Lamster and Joseph K. Ahlo 15. Oral Fluid-Based Biomarkers of Alveolar Bone Loss in Periodontitis: Janet S. Kinney, Christoph A. Ramseier, and William V. Giannobile 16. Human Breath Odors and Their Use in Diagnosis: Chris L. Whittle, Steven Fakharzadeh, Jason Eades, and George Preti Part V: Molecular and Protein Markers of Disease: 17. Molecular and Protein Markers of Disease: Michael Glick 18. Subclinical Cardiovascular Disease Markers Applicable to Studies of Oral Health: Multiethnic Study of Atherosclerosis: David R. Jacobs, Jr., and Richard S. Crow 19. Do Salivary Antibodies Reliably Reflect Both Mucosal and Systemic Immunity?: Per Brandtzaeg 20. Oxytocin: Behavioral Associations and Potential as a Salivary Biomarker: C. Sue Carter, Hossein Pournajafi-Nazarloo, Kristin M. Kramer, Toni E. Ziegler, Rosemary White-Traut, Deborah Bello, and Dorie Schwertz 21. Human Saliva Proteome Analysis: Shen Hu, Joseph A. Loo, and David T. Wong Part VI: Horizons in Oral Diagnostics: 22. Genomics and Proteomics: The Potential Role of Oral Diagnostics: Hans J. Tanke 23. SPR Imaging-Based Salivary Diagnostics System for the Detection of Small Molecule Analytes: Elain Fu, Timothy Chinowsky, Kjell Nelson, Kyle Johnston, Thayne Edwards, Kristen Helton, Michael Grow, John W. Miller, and Paul Yager 24. Saliva-Based Diagnostics Using 16S rRNA Microarrays and Microfluidics: E. Michelle Starke, James C. Smoot, Jer-Horng Wu, Wen-Tso Liu, Darrell Chandler, and David A. Stahl 25. Integrated Microfluidic Platform for Oral Diagnostics: Amy E. Herr, Anson V. Hatch, William V. Giannobile, Daniel J. Throckmorton, Huu M. Tran, James S. Brennan, and Anup K. Singh 26. Development of a Microfluidic Device for Detection of Pathogens in Oral Samples Using Upconverting Phosphor Technology (UPT): William R. Abrams, Cheryl A. Barber, Kurt McCann, Gary Tong, Zongyuan Y. Chen, Michael G. Mauk, Jing Wang, Alex Volkov, Pete Bourdelle, Paul L. A. M. Corstjens, Michel Zuiderwijk, Keith Kardos, Shang Li, Hans J. Tanke, R. Sam Niedbala, Daniel Malamud, and Haim Bau 27. Microsensor Arrays for Saliva Diagnostics: David R. Walt, Timothy M. Blicharz, Ryan B. Hayman, David M. Rissin, Michaela Bowden, Walter L. Siqueira, Eva J. Helmerhorst, Nerline Grand-Pierre, Frank G. Oppenheim, Jasvinder S. Bhatia, Frederic F. Little, and Jerome S. Brody 28. Oral Fluid Nanosensor Test (OFNASET) with Advanced Electrochemical-Based Molecular Analysis Platform: Vincent Gau and David Wong 29. Lab-on-a-Chip Methods for Point-of-Care Measurements of Salivary Biomarkers of Periodontitis: Nicolaos Christodoulides, Pierre N. Floriano, Craig S. Miller, Jeffrey L. Ebersole, Sanghamitra Mohanty, Priya Dharshan, Michael Griffin, Alexis Lennart, Karri L. Michael Ballard, Charles P. King, Jr., M. Chris Langub, Richard J. Kryscio, Mark V. Thomas, and John T. McDevitt Part VII: Short Papers: 30. A Microfluidic System for Saliva-Based Detection of Infectious Diseases: Zongyuan Chen, Michael G. Mauk, Jing Wang, William R. Abrams, Paul L. A. M. Corstjens, R. Samuel Niedbala, Daniel Malamud, and Haim H. Bau 31. Rapid Assay Format for Multiplex Detection of Humoral Immune Responses to Infectious Disease Pathogens (HIV, HCV, and TB): Paul L. A. M. Corstjens, Zongyuang Chen, Michel Zuiderwijk, Haim H. Bau, William R. Abrams, Daniel Malamud, R. Sam Niedbala, and Hans J. Tanke 32. Patterns of Salivary Estradiol and Progesterone across the Menstrual Cycle: Beatrice K. Gandara, Linda Leresche, and Lloyd Mancl 33. Layered Peptide Arrays: A Diverse Technique for Antibody Screening of Clinical Samples: Gallya Gannot, Michael A. Tangrea, Rodrigo F. Chuaqui, John W. Gillespie, and Michael R. Emmert-Buck 34. Whole Saliva Proteolysis: Wealth of Information for Diagnostic Exploitation: Eva J. Helmerhorst 35. Saliva-Based HIV Testing among Secondary School Students in Tanzania using the OraQuick® Rapid HIV1/2 Antibody Assay: Carol Holm-Hansen, Balthazar Nyombi, and Mramba Nyindo 36. Lab-on-a-Chip Technologies for Oral-Based Cancer Screening and Diagnostics: Capabilities, Issues, and Prospects: Michael G. Mauk, Barry L. Ziober, Zongyuan Chen, Jason A. Thompson, and Haim H. Bau 37. Evaluation of UPlink-RSV: Prototype Rapid Antigen Test for Detection of Respiratory Syncytial Virus Infection: Vijaya K. Mokkapati, R. Sam Niedbala, Keith Kardos, Ronelito J. Perez, Ming Guo, Hans J. Tanke, and Paul L. A. M. Corstjens 38. Immunoassay-Based Diagnostic Point-of-Care Technology for Oral Specimen: Sarvan Munjal, Peter Miethe, Lutz Netuschil, Friedhelm Struck, Kurt Maier, and Claus Bauermeister 39. Evaluation of Immunoassay-Based MMP-8 Detection in Gingival Crevicular Fluid on a Point-of-Care Platform: S. K. Munjal, N. Prescher, F. Struck, T. Sorsa, K. Maier, and L. Netuschil 40. Rapid Quantitative Chairside Test for Active MMP-8 in Gingival Crevicular Fluid: First Clinical Data: N. Prescher, K. Maier, S. K. Munjal, T. Sorsa, C.-D. Bauermeister, F. Struck, and L. Netuschil 41. Salivary Biomarkers Associated with Alveolar Bone Loss: F. A. Scannapieco, Pby Ng, K. Hovey, E. Hausmann, A. Hutson, and J. Wactawski-Wende 42. Salivary Protein/Peptide Profiling with SELDI-TOF-MS: Raymond Schipper, Arnoud Loof, Jolan De Groot, Lucien Harthoorn, Waander Van Heerde, and Eric Dransfield 43. Acquired Enamel Pellicle and Its Potential Role in Oral Diagnostics: W. L. Siqueira, E. J. Helmerhorst, W. Zhang, E. Salih, and F. G. Oppenheim 44. Gender-Specific Differences in Salivary Biomarker Responses to Acute Psychological Stress: Noriyasu Takai, Masaki Yamaguchi, Toshiaki Aragaki, Kenji Eto, Kenji Uchihashi, and Yasuo Nishikawa

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