**Selected for 2025 Doody’s Core Titles® in Infectious Disease**

Offering more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource, Mandell, Douglas, and Bennett`s Principles and Practice of Infectious Diseases, 10th Edition, remains your #1 choice for authoritative, comprehensive information in this challenging field. Meticulously updated by a new editorial team led by Drs. Martin J. Blaser, Jeffrey I. Cohen, and Steven M. Holland, this two-volume masterwork brings together the knowledge and expertise of more than 650 contributing authors who are outstanding scholars and experts in their fields. For ID specialists and general practitioners alike, PPID provides a balanced, detailed perspective for any patient you encounter with a complex or difficult-to-treat infectious disease. Encyclopedic in its depth, contents, and referencing, PPID-10 is the one infectious disease book that needs to be on every practitioner’s shelf and in every medical library.

Key Features
Organizes content both by individual pathogens and by important clinical syndromes, broadening the context to clearly present relevant, complex clinical information.
Contains multiple new chapters on both SARS-CoV-2 and anti-fungal therapy, as well as new chapters on bacteriophages and related agents, infections following traumatic injuries, communication to the public about infectious diseases, and the effects of climate change on infectious diseases.
Provides up-to-date coverage of recent advances in the field: an increasing understanding of the agents, immune responses, and the growing armamentarium of diagnostics (such as nucleic acid amplification and next-generation sequencing); new treatments (such as monoclonal antibodies, new antifungals, antivirals, and phage therapy); and emerging preventive measures (such as new vaccines being developed for RSV), and our relationship with the human microbiome.
Features more than 1,500 high-quality, full-color photographs―with many new to this edition.
Shares the extensive experience of new editors Drs. Jeffrey I. Cohen and Steven M. Holland, both from Bethesda, MD, as well as a new team of expert associate editors Drs. Yohei Doi, Wendy S. Garrett, Ann R. Falsey, Eleanor Wilson, Kieren Marr, and Edward Mitre—each a leading authority in their field.
Includes perspectives from hundreds of leading experts from a truly global community, including authors from Australia, Canada, and countries in Europe, Asia, and South America.
Includes regular updates online for the life of the edition.
An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.

Author Information
Edited by Martin J. Blaser, MD, Henry Rutgers Chair of the Human Microbiome, Professor of Medicine and Pathology & Laboratory Medicine - RWJMS; Director, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey, USA; Jeffrey I. Cohen, MD, Bethesda, MD and Steven M. Holland, MD, Bethesda, MD

PART I: BASIC PRINCIPLES IN THE DIAGNOSIS AND MANAGEMENT OF INFECTIOUS DISEASES
Section A: Microbial Pathogens
1. A Molecular Perspective of Microbial Pathogenicity
2. The Human Microbiome
3. Prebiotics, Probiotics, and Synbiotics

Section B: Host Defense Mechanisms
4. Innate (General or Nonspecific) Host Defense Mechanisms
5. Adaptive Immunity: Antibodies and Immunodefiencies
6. Cell-Mediated Defense Against Infection
7. Mucosal Immunity
8. Granulocytic Phagocytes
9. Complement and Deficiencies
10. Human Genetics and Infection
11. Nutrition, Immunity, and Infection
12. Evaluation of the Patient with Suspected Immunodeficiency

Section C: Epidemiology of Infectious Disease
13. Principles of Applied Epidemiology for the Practice of Infectious Diseases
14. Emerging and Reemerging Infectious Disease Threats
15. Bioterrorism: An Overview

Section D: Clinical Microbiology
16. The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result Interpretation

Section E: Antiinfective Therapy
17. Principles of Anti-Infective Therapy
18. Molecular Mechanisms of Antibiotic Resistance in Bacteria
19. Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents
20. Penicillins and β-Lactamase Inhibitors
21. Cephalosporins and Cephalosporin/β-Lactamase Inhibitor Combinations
22. Carbapenems, Carbapenem/β-Lactamase Inhibitor Combinations, and Aztreonam
23. Antibiotic Allergy
24. Aminoglycosides
25. Tetracyclines, Tetracycline Derivatives, and Chloramphenicol
26. Rifamycins
27. Metronidazole
28. Macrolides and Clindamycin
29. Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin)
30. Streptogramins (Quinupristin-Dalfopristin) and Lipopeptides (Daptomycin)
31. Polymyxins (Polymyxin B and Colistin)
32. Linezolid,Tedizolid, and Other Oxazolidinones
33. Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole
34. Quinolones
35. Antibiotics in Advanced Development and Other Agents
36. Urinary Tract Agents: Nitrofurantoin, Fosfomycin and Methenamine
37. Topical Antibacterials
38. Antimycobacterial Agents
39. Bacteriophage Therapy, Endolysin Therapy and Antimicrobial Peptide Therapy
40. Antifungal Agents: Polyene Antifungals
41. Antifungal Drugs: Azole
42. Antifungal Drugs: Echinocandins and Other Beta-D-glucan Inhibitors
43. Antifungal Drugs: Flucytosine
44. Antimalarial Drugs
45. Drugs for Protozoal Infections Other Than Malaria
46. Drugs for Helminths
47. Antiviral Agents: General Principles
48. Antiviral Drugs for Influenza and Other Respiratory Virus Infections Except for SARS-CoV-2
49. Antivirals Against Herpesviruses
50. Antiviral Drugs Against Hepatitis Viruses
51. Miscellaneous Antivirals Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir)
52. Immunomodulators
53. Hyperbaric Oxygen
54. Antimicrobial Stewardship
55. Designing and Interpreting Clinical Studies in Infectious Diseases
56. Outpatient Parenteral Antimicrobial Therapy

PART II: MAJOR CLINICAL SYNDROMES
Section A: Fever
57. Temperature Regulation and the Pathogenesis of Fever
58. Fever of Unknown Origin
59. The Acutely Ill Patient with Fever and Rash

Section B: Upper Respiratory Tract Infections
60. The Common Cold
61. Pharyngitis
62. Acute Laryngitis
63. Otitis Externa, Otitis Media, and Mastoiditis
64. Sinusitis
65. Epiglottitis
66. Infections of the Oral Cavity, Neck, and Head

Section C: Pleuropulmonary and Bronchial Infections
67. Acute Bronchitis
68. Acute Exacerbations of Chronic Obstructive Pulmonary Disease
69. Acute Pneumonia
70. Pleural Effusion and Empyema
71. Bacterial Lung Abscess
72. Chronic Pneumonia
73. Cystic Fibrosis

Section D: Urinary Tract Infections
74. Urinary Tract Infections

Section E: Sepsis
75. Sepsis and Septic Shock

Section F: Intraabdominal Infections
76. Peritonitis and Intraperitoneal Abscesses
77. Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis)
78. Pancreatic Infection
79. Splenic Abscess
80. Appendicitis
81. Diverticulitis and Neutropenic Enterocolitis

Section G: Cardiovascular Infections
82. Endocarditis and Intravascular Infections
83. Prosthetic Valve Endocarditis
84. Infections of Nonvalvular Cardiovascular Devices
85. Prophylaxis of Infective Endocarditis
86. Myocarditis and Pericarditis
87. Mediastinitis

Section H: Central Nervous System Infections
88. Approach to the Patient with Central Nervous System Infection
89. Acute Meningitis
90. Chronic Meningitis
91. Encephalitis
92. Brain Abscess
93. Subdural Empyema, Epidural Abscess, and Suppurative Intracranial Thrombophlebitis
94. Cerebrospinal Fluid Shunt and Drain Infections

Section I: Skin and Soft Tissue Infections
95. Cellulitis, Necrotizing Fasciitis, and Subcutaneous Tissue Infections
96. Myositis and Myonecrosis
97. Lymphadenitis and Lymphangitis

Section J: Gastrointestinal Infections and Food Poisoning
98. Syndromes of Enteric Infection
99. Esophagitis
100. Diarrhea with Little or No Fever
101. Acute Dysentery Syndromes (Diarrhea with Fever)
102. Typhoid Fever, Paratyphoid Fever, and Typhoidal Fevers
103. Foodborne Disease (Food Poisoning)
104. Tropical Sprue and Environmental Enteric Dysfunction

Section K: Bone and Joint Infections
105. Infectious Arthritis of Native Joints
106. Osteomyelitis
107. Orthopaedic Implant-Associated Infections

Section L: Diseases of The Reproductive Organs and Sexually Transmitted Diseases
108. Anogenital Skin and Mucous Membrane Lesions
109. Urethritis
110. Vulvovaginitis and Cervicitis
111. Infections of the Female Pelvis
112. Prostatitis, Epididymitis, and orchitis

Section M: Eye Infections
113. Introduction to Eye Infections
114. Microbial Conjunctivitis
115. Microbial Keratitis
116. Endophthalmitis
117. Infectious Causes of Uveitis
118. Periocular Infections

Section N: Hepatitis
119. Viral Hepatitis

Section O: Acquired Immunodeficiency Syndrome
120. Human Immunodeficiency Viruses
121. Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
122. Epidemiology and Prevention of AIDS and HIV Infection, Including Preexposure Prophylaxis and HIV Vaccine Development
123. Diagnosis of Human Immunodeficiency Virus Infection
124. The Immunology of HIV-1 Infection, Mechanisms of Viral Persistence, and Prospects for Cure
125. General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic, and Cardiac Diseases)
126. Pulmonary Manifestations of Human Immunodeficiency Virus Infection
127. Gastrointestinal Hepatobiliary and Pancreatic Manifestations of Human Immunodeficiency Virus Infection
128. Neurologic Diseases Caused By Human Immunodeficiency Virus Type 1 and Opportunistic Infections
129. Pediatric Human Immunodeficiency Virus Infection
130. Antiretroviral Therapy for Human Immunodeficiency Virus Infection
131. Management of Opportunistic Infections Associated with Human Immunodeficiency Virus Infection

Section P: COVID-19
132. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Virology
133. Global perspective and Epidemiology of COVID-19
134. Immunology and Diagnosis of SARS-CoV-2 and COVID-19
135. Clinical Manifestations of COVID-19 in Adults and Children
136. Treatment and Prevention of SARS-CoV-2 (COVID-19)

Section Q: Miscellaneous Syndromes
137. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome


PART III: INFECTIOUS DISEASES AND THEIR ETIOLOGIC AGENTS
Section A: Viral Diseases
138. Biology of Viruses and Viral Diseases
139. Orthopoxviruses: Vaccinia (Smallpox Vaccine), Variola (Smallpox), Mpox, and Cowpox
140. Other Poxviruses That Infect Humans: (Including Orf Virus) Molluscum Contagiosum, and Yatapoxviruses
141. Introduction to Herpesviridae
142. Herpes Simplex Virus
143. Chickenpox and Herpes Zoster (Varicella-Zoster Virus)
144. Cytomegalovirus
145. Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus–Associated Malignant Diseases, and Other Diseases)
146. Human Herpesvirus Types 6 and 7 (Exanthem Subitum)
147. Kaposi’s Sarcoma–Associated Herpesvirus (Human Herpesvirus Type 8)
148. Herpes B Virus
149. Adenoviruses
150. Papillomaviruses
151. JC, BK, and Other Polyomaviruses: Progressive Multifocal Leukoencephalopathy, BK Nephropathy, and Merkel Cell Carcinoma
152. Hepatitis B Virus
153. Hepatitis D Virus
154. Human Parvoviruses, Including Parvovirus B19, Human Bocaviruses, and Adeno-Associated Viruses (AAVs)
155. Orthoreoviruses and Orbiviruses
156. Coltiviruses (Colorado Tick Fever Virus) and Seadornaviruses
157. Rotaviruses
158. Alphaviruses
159. Rubella Virus (German Measles)
160. Flaviviruses (Dengue, Yellow Fever, Japanese Encephalitis, West Nile Encephalitis, Usutu Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis, Powassan Encephalitis, Kyasanur Forest Disease, Alkhurma Hemorrhagic Fever, Zika)
161. Hepatitis C
162. Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS)
163. Parainfluenza Viruses
164. Mumps Virus
165. Respiratory Syncytial Virus
166. Human Metapneumovirus
167. Measles Virus (Rubeola)
168. Zoonotic Paramyxoviruses: Nipah, Hendra, and Menangle Viruses
169. Vesicular Stomatitis Virus and Related Vesiculoviruses (Chandipura Virus)
170. Rabies (Rhabdoviruses)
171. Marburg and Ebola Virus Hemorrhagic Fevers
172. Influenza Viruses, Including Avian Influenza and Swine Influenza
173. Bunyavirus Infections: Hantavirus Syndromes, La Crosse encephalitis, Rift Valley Fever, Crimean-Congo Hemorrhagic Fever, and Others
174. Lymphocytic Choriomeningitis Virus, Lassa Virus, Lujo Virus, and the South American Hemorrhagic Fever Viruses (Arenaviruses)
175. Human T-Lymphotropic Virus
176. Introduction to the Human Enteroviruses and Parechoviruses
177. Poliovirus
178. Coxsackieviruses, Echoviruses and Numbered Enteroviruses (EVD-68, EVD-70, EV-A71) )
179. The Human Parechoviruses
180. Hepatitis A Virus
181. Rhinovirus
182. Noroviruses and Sapoviruses (Caliciviruses)
183. Astroviruses and Picobirnaviruses
184. Hepatitis E Virus

Section B: Prion Diseases
185. Prions and Prion Diseases of the Central Nervous System (Transmissible Neurodegenerative Diseases)

Section C: Chlamydial Diseases
186. Chlamydia Trachomatis (Urogenital Infections and Trachoma)
187. Psittacosis (Due to Chlamydia psittaci)
188. Chlamydia Pneumoniae

Section D: Mycoplasma Diseases
189. Mycoplasmoides (Mycoplasma) pneumoniae
190. Genital Mycoplasmas: Mycoplasma Genitalium, Mycoplasma Hominis, Ureaplasma Species

Section E: Rickettsioses, Ehrlichioses, and Anaplasmoses
191. Introduction to Rickettsioses, Ehrlichioses, and Anaplasmosis
192. Rickettsia Rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)
193. Coxiella Burnetii (Q Fever)
194. Rickettsia Prowazekii (Epidemic or Louse-Borne Typhus)
195. Rickettsia Typhi (Murine Typhus)
196. Orientia Tsutsugamushi (Scrub Typhus)
197. Ehrlichia chaffeensis, Anaplasma phagocytophilum, and Other Anaplasmataceae

Section F: Bacterial Diseases
198. Introduction to Bacteria and Bacterial Diseases

Sub-Section I. Infections due to Gram-Positive Bacteria
199. Staphylococcus Aureus
200. Staphylococcus Epidermidis and Other Coagulase-Negative Staphylococci
201. Classification of Streptococci
202. Streptococcus Pyogenes (Group A streptococcus)
203. Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis
204. Streptococcus Pneumoniae
205. Enterococcus Species, Streptococcus Gallolyticus Group and Leuconostoc Species
206. Streptococcus Agalactiae (Group B Streptococcus)
207. Viridans Streptococci, Nutritionally Variant Streptococci, and Groups C and G Streptococci
208. Streptococcus Anginosus Group
209. Corynebacterium Diphtheriae (Diphtheria)
210. Other Coryneform Bacteria and Rhodococci
211. Listeria Monocytogenes
212. Bacillus Anthracis (Anthrax)
213. Bacillus Species and Related Genera Other Than Bacillus Anthracis
214. Erysipelothrix Rhusiopathiae
215. Whipple Disease

Sub-Section II. Infections due to Gram-Negative Bacteria
216. Neisseria Meningitidis
217. Neisseria Gonorrhoeae (Gonorrhea)
218. Moraxella Catarrhalis, Kingella, and Other Gram-Negative Cocci
219. Vibrio Cholerae
220. Other Pathogenic Vibrios
221. Campylobacter Jejuni and Related Species
222. Helicobacter Pylori and Other Gastric Helicobacter Species
223. Enterobacterales (Enterobacteriaceae)
224. P. Aeruginosa and Other Pseudomonas Species
225. Stenotrophomonas Maltophilia and Burkholderia Cepacia Complex
226. Burkholderia Pseudomallei and Burkholderia Mallei: Melioidosis and Glanders
227. Acinetobacter Species
228. Salmonella Species
229. Bacillary Dysentery: Shigella and Enteroinvasive Escherichia coli
230. Haemophilus Species, Including H. Influenzae and H. ducreyi
231. Brucellosis (Brucella Species)
232. Francisella Tularensis (Tularemia)
233. Pasteurella Species
234. Plague (Yersinis Pestis)
235. Yersinia Enterocolitica and Yersinia Pseudotuberculosis
236. Bordetella Pertussis
237. Rat-Bite Fever: Streptobacillus Moniliformis and Spirillum Minus
238. Legionnaires’ Disease and Pontiac Fever
239. Capnocytophaga Species
240. Bartonella, Including Cat-Scratch Disease
241. Klebsiella Granulomatis (Donovanosis, Granuloma Inguinale)
242. Other Gram-Negative and Gram-Variable Bacilli

Sub-Section III. Infections due to Spirochetal Bacteria
243. Syphilis (Treponema Pallidum)
244. Endemic Treponematoses
245. Leptospira Species (Leptospirosis)
246. Relapsing Fevers Due to Borrelia Species
247. Lyme Disease (Lyme Borreliosis) Due to Borrelia Burgdorferi

Sub-Section IV. Infections due to Anaerobic Bacteria
248. Anaerobic Infections: General Concepts
249. Clostridioides (Clostridium) difficile Infection
250. Tetanus (Clostridium Tetani)
251. Botulism (Clostridium Botulinum)
252. Diseases Caused by Clostridium
253. Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (And Other Medically Important Anaerobic Gram-Negative Bacilli)
254. Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli

Sub-Section V. Infections due to Acid-Fast Organisms
255. Mycobacterium Tuberculosis
256. Leprosy (Mycobacterium Leprae)
257. Mycobacterium Avium Complex
258. Infections Caused by Nontuberculous Mycobacteria Other Than Mycobacterium Avium Complex
259. Nocardia Species
260. Agents of Actinomycosis

Section G: Mycoses
261. Introduction to Mycoses
262. Candida Species
263. Aspergillus Species
264. Agents of Mucormycosis and Entomophthoramycosis
265. Sporothrix Schenckii
266. Chromoblastomycosis
267. Mycetoma
268. Cryptococcosis (Cryptococcus Neoformans and Cryptococcus Gattii)
269. Histoplasma Capsulatum (Histoplasmosis)
270. Blastomycosis
271. Coccidioidomycosis (Coccidioides Species)
272. Dermatophytosis (Ringworm) and Other Superficial Mycoses
273. Paracoccidioidomycosis
274. Uncommon Fungi and Related Species
275. Pneumocystis Species
276. Microsporidiosis

Section H: Protozoal Diseases
277. Introduction to Protozoal Diseases
278. Entamoeba Species, Including Amebic Colitis and Liver Abscess
279. Free-Living Amebae
280. Malaria (Plasmodium Species)
281. Leishmania Species: Visceral, Cutaneous, and Mucosal
282. Trypanosoma Species (American Trypanosomiasis, Chagas Disease): Biology of Trypanosomes
283. Agents of African Trypanosomiasis (Sleeping Sickness)
284. Toxoplasma Gondii
285. Giardia Lamblia
286. Trichomonas Vaginalis
287. Babesia Species
288. Cryptosporidiosis (Cryptosporidium Species)
289. Cyclospora Cayetanensis, Isospora Belli, Sarcocystis Species, Balantidium Coli, and Blastocystis Species

Section I: Diseases Due to Toxic Algae
290. Human Illness Associated With Cyanobacteria and Harmful Algal Blooms, Including Fish and Shellfish Poisoning Syndromes

Section J: Diseases Due to Helminths
291. Introduction to Helminth Infections
292. Intestinal Nematodes (Roundworms)
293. Tissue Nematodes, Including Trichinellosis, Dracunculiasis, and the Filariases
294. Trematodes (Schistosomes and Liver, Intestinal and Lung Flukes)
295. Tapeworms (Cestodes)
296. Visceral Larva Migrans and Other Uncommon Helminth Infections

Section K: Ectoparasitic Diseases
297. Introduction to Ectoparasitic Diseases
298. Lice (Pediculosis)
299. Scabies
300. Myiasis and Tungiasis
301. Mites, Including Chiggers

Section L: Diseases of Unknown Etiology
302. Ticks, Including Tick Paralysis
303. Kawasaki Disease

PART IV: SPECIAL PROBLEMS
Section A: Nosocomial Infections
304. Infection Prevention and Control in the Healthcare Setting
305. Disinfection, Sterilization, and Hospital Waste
306. Infections Caused by Percutaneous Intravascular Devices
307. Nosocomial Pneumonia
308. Catheter-Associated Urinary Tract Infection (CAUTI) and Catheter-Associated Asymptomatic Bacteriuria (CA-ASB)
309. Transfusion- and Transplantation-Transmitted Infections

Section B: Infections in Special Hosts
310. Infections in the Immunocompromised Host: General Principles
311. Prophylaxis and Empirical Therapy of Infection in Cancer Patients
312. Infections in Recipients of Hematopoietic Cell Transplantation +CAR-Tcell infections
313. Infections in Solid organ Transplant Recipients
314. Infections in Older Adults
315. Infections in Asplenic Patients
316. Infections in Persons Who Inject Drugs

Section C: Surgical- and Trauma-Related Infections
317. Surgical Site Infections and Antimicrobial Prophylaxis
318. Burns
319. Infections Following Traumatic Injuries
320. Bites

Section D: Immunization
321. Principles of immunization and public health
322. Immunizations for Specific Infections

Section E: Protection of Travelers
323. Protection of Travelers
324. Infections in Returning Travelers

Section F: Emerging Issues in Infectious Diseases
325. Zoonoses
326. Communicating about Infectious Diseases to the Public
327. Basic Principles in Climate Change and Infectious Diseases

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