Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine

The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms

Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.

Essential for practice and education, the landmark 20th Edition features:

Thoroughly revised content―covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.

State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.

All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine― Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.

Important and timely new chapters―such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more―offer the very latest, definitive perspectives on must-know topics in medical education and practice. 

Updated clinical guidelines, expert opinions, and treatment approaches from renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes.

CONTRIBUTORS PREFACE Part 1: The Profession of Medicine 1 The Practice of MedicineThe Editors

2 Promoting Good HealthDonald M. Lloyd-Jones, Kathleen M. McKibbin

3 Decision-Making in Clinical MedicineDaniel B. Mark, John B. Wong

4 Screening and Prevention of DiseaseKatrina A. Armstrong, Gary J. Martin

5 Health Care Systems in Developed CountriesRichard B. Saltman

6 The Safety and Quality of Health CareDavid W. Bates

7 Racial and Ethnic Disparities in Health CareJoseph R. Betancourt, Alexander R. Green

8 Ethical Issues in Clinical MedicineBernard Lo, Christine Grady

9 Palliative and End-of-Life CareEzekiel J. Emanuel Part 2: Cardinal Manifestations and Presentation of Diseases Section 1: Pain 10 Pain: Pathophysiology and ManagementJames P. Rathmell, Howard L. Fields

11 Chest DiscomfortDavid A. Morrow

12 Abdominal PainDanny O. Jacobs

13 HeadachePeter J. Goadsby

14 Back and Neck PainJohn W. Engstrom Section 2: Alterations in Body Temperature 15 FeverCharles A. Dinarello, Reuven Porat

16 Fever and RashElaine T. Kaye, Kenneth M. Kaye

17 Fever of Unknown OriginChantal P. Bleeker-Rovers, Jos W. M. van der Meer Section 3: Nervous System Dysfunction 18 SyncopeRoy Freeman

19 Dizziness and VertigoMark F. Walker, Robert B. Daroff

20 FatigueJeffrey M. Gelfand, Vanja C. Douglas

21 Neurologic Causes of ?Weakness and ParalysisMichael J. Aminoff

22 Numbness, Tingling, and Sensory LossMichael J. Aminoff

23 Gait Disorders, Imbalance and FallsJessica M. Baker, Lewis R. Sudarsky

24 Confusion and DeliriumS. Andrew Josephson, Bruce L. Miller

25 DementiaWilliam W. Seeley, Bruce L. Miller

26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes and Other Cerebral DisordersM.-Marsel Mesulam

27 Sleep DisordersThomas E. Scammell, Clifford B. Saper, Charles A. Czeisler Section 4: Disorders of Eyes, Ears, Nose, and Throat 28 Disorders of the EyeJonathan C. Horton

29 Disorders of Smell and TasteRichard L. Doty, Steven M. Bromley

30 Disorders of HearingAnil K. Lalwani

31 Sore Throat, Earache, and Upper Respiratory SymptomsMichael A. Rubin, Larry C. Ford, Ralph Gonzales

32 Oral Manifestations of DiseaseSamuel C. Durso Section 5: Alterations in Circulatory and Respiratory Functions 33 DyspneaRebecca M. Baron

34 Cough Christopher H. Fanta

35 HemoptysisAnna K. Brady, Patricia A. Kritek

36 Hypoxia and CyanosisJoseph Loscalzo

37 EdemaEugene Braunwald, Joseph Loscalzo

38 Approach to the Patient with a Heart MurmurPatrick T. O’Gara, Joseph Loscalzo

39 PalpitationsJoseph Loscalzo Section 6: Alterations in Gastrointestinal Function 40 DysphagiaIkuo Hirano, Peter J. Kahrilas

41 Nausea, Vomiting, and IndigestionWilliam L. Hasler

42 Diarrhea and ConstipationMichael Camilleri, Joseph A. Murray

43 Unintentional Weight LossJ. Larry Jameson

44 Gastrointestinal BleedingLoren Laine

45 JaundiceSavio John, Daniel S. Pratt

46 Abdominal Swelling and AscitesKathleen E. Corey, Lawrence S. Friedman Section 7: Alterations in Renal and Urinary Tract Function 47 Dysuria, Bladder Pain, and the Interstitial Cystitis/ Bladder Pain SyndromeJohn W. Warren

48 Azotemia and Urinary AbnormalitiesDavid B. Mount

49 Fluid and Electrolyte DisturbancesDavid B. Mount

50 Hypercalcemia and HypocalcemiaSundeep Khosla

51 Acidosis and AlkalosisThomas D. DuBose, Jr. Section 8: Alterations in the Skin 52 Approach to the Patient with a Skin DisorderKim B. Yancey, Thomas J. Lawley

53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin DisordersLeslie P. Lawley, Calvin O. McCall, Thomas J. Lawley

54 Skin Manifestations of Internal DiseaseJean L. Bolognia, Irwin M. Braverman

55 Immunologically Mediated Skin DiseasesKim B. Yancey, Thomas J. Lawley

56 Cutaneous Drug ReactionsRobert G. Micheletti, Misha Rosenbach, Bruce U. Wintroub, Kanade Shinkai

57 Photosensitivity and Other Reactions to LightAlexander G. Marneros, David R. Bickers Section 9: Hematologic Alterations 58 Interpreting Peripheral Blood Smears Dan L. Longo

59 Anemia and PolycythemiaJohn W. Adamson, Dan L. Longo

60 Disorders of Granulocytes and MonocytesSteven M. Holland, John I. Gallin

61 Bleeding and ThrombosisBarbara A. Konkle

62 Enlargement of Lymph Nodes and SpleenDan L. Longo Part 3: Pharmacology 63 Principles of Clinical PharmacologyDan M. Roden

64 PharmacogenomicsDan M. Roden Part 4: Oncology and Hematology Section 1: Neoplastic Disorders 65 Approach to the Patient with CancerDan L. Longo

66 Prevention and Early Detection of ?CancerJennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer

67 Cancer GeneticsFred Bunz, Bert Vogelstein

68 Cancer Cell BiologyJeffrey W. Clark, Dan L. Longo

69 Principles of Cancer TreatmentEdward A. Sausville, Dan L. Longo

70 Infections in Patients with CancerRobert W. Finberg

71 Oncologic EmergenciesRasim Gucalp, Janice P. Dutcher

72 Cancer of the SkinBrendan D. Curti, Sancy Leachman, Walter J. Urba

73 Head and Neck CancerEverett E. Vokes

74 Neoplasms of the LungLeora Horn, Christine M. Lovly

75 Breast CancerDaniel F. Hayes, Marc E. Lippman

76 Upper Gastrointestinal Tract CancersRobert J. Mayer

77 Lower Gastrointestinal CancersRobert J. Mayer

78 Tumors of the Liver and Biliary TreeJosep M. Llovet

79 Pancreatic CancerDaniel D. Von Hoff

80 Neuroendocrine Tumors of the Gastrointestinal Tract and PancreasRobert T. Jensen

81 Renal Cell CarcinomaRobert J. Motzer

82 Cancer of the Bladder and Urinary TractNoah M. Hahn

83 Benign and Malignant Diseases of the ProstateHoward I. Scher, James A. Eastham

84 Testicular CancerDavid J. Vaughn

85 Gynecologic MalignanciesDavid Spriggs

86 Primary and Metastatic Tumors of the Nervous SystemLisa M. DeAngelis, Patrick Y. Wen

87 Soft Tissue and Bone Sarcomas and Bone MetastasesShreyaskumar R. Patel

88 Carcinoma of Unknown PrimaryGauri R. Varadhachary, James L. Abbruzzese

89 Paraneoplastic Syndromes: Endocrinologic/HematologicJ. Larry Jameson, Dan L. Longo

90 Paraneoplastic Neurologic Syndromes and Autoimmune EncephalitisJosep Dalmau, Myrna R. Rosenfeld

91 Late Consequences of Cancer and Its TreatmentCarl E. Freter, Dan L. Longo Section 2: Hematopoietic Disorders 92 Hematopoietic Stem CellsDavid T. Scadden, Dan L. Longo

93 Iron Deficiency and Other Hypoproliferative AnemiasJohn W. Adamson

94 Disorders of HemoglobinEdward J. Benz, Jr.

95 Megaloblastic AnemiasA. Victor Hoffbrand

96 Hemolytic Anemias Lucio Luzzatto

97 Anemia Due to Acute Blood LossDan L. Longo

98 Bone Marrow Failure Syndromes Including Aplastic Anemia and MyelodysplasiaNeal S. Young

99 Polycythemia Vera and Other Myeloproliferative NeoplasmsJerry L. Spivak

100 Acute Myeloid LeukemiaWilliam Blum, Clara D. Bloomfield

101 Chronic Myeloid LeukemiaHagop Kantarjian, Jorge Cortes

102 Acute Lymphoid LeukemiaDieter Hoelzer

103 Chronic Lymphocytic LeukemiaJennifer A. Woyach, John C. Byrd

104 Non-Hodgkin’s LymphomaCaron A. Jacobson, Dan L. Longo

105 Hodgkin`s Lymphoma Caron A. Jacobson, Dan L. Longo

106 Less Common Hematologic MalignanciesAyalew Tefferi, Dan L. Longo

107 Plasma Cell DisordersNikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson

108 AmyloidosisJohn L. Berk, Vaishali Sanchorawala

109 Transfusion Biology and TherapyJeffery S. Dzieczkowski, Pierre Tiberghien, Kenneth C. Anderson

110 Hematopoietic Cell TransplantationFrederick R. Appelbaum Section 3: Disorders of Hemostasis 111 Disorders of Platelets and Vessel WallBarbara A. Konkle

112 Coagulation DisordersValder R. Arruda, Katherine A. High

113 Arterial and Venous ThrombosisJane E. Freedman, Joseph Loscalzo

114 Antiplatelet, Anticoagulant, and Fibrinolytic DrugsJeffrey I. Weitz Part 5: Infectious Diseases Section 1: Basic Considerations in Infectious Diseases 115 Approach to the Patient with an Infectious DiseaseNeeraj K. Surana, Dennis L. Kasper

116 Molecular Mechanisms of Microbial PathogenesisGerald B. Pier

117 Approach to the Acutely Ill Infected Febrile PatientTamar F. Barlam, Dennis L. Kasper

118 Immunization Principles and Vaccine UseNancy Messonnier, Anne Schuchat, Lisa A. Jackson

119 Health Recommendations for International TravelJay S. Keystone, Phyllis E. Kozarsky

120 Climate Change and Infectious DiseaseAaron S. Bernstein Section 2: Clinical Syndromes: Community-Acquired Infections 121 PneumoniaLionel A. Mandell, Richard G. Wunderink

122 Lung AbscessRebecca M. Baron, Miriam Baron Barshak

123 Infective EndocarditisAdolf W. Karchmer

124 Infections of the Skin, Muscles, and Soft TissuesDennis L. Stevens

125 Infectious ArthritisLawrence C. Madoff

126 OsteomyelitisWerner Zimmerli

127 Intraabdominal Infections and AbscessesMiriam Baron Barshak, Dennis L. Kasper

128 Acute Infectious Diarrheal Diseases and Bacterial Food PoisoningRichelle C. Charles, Stephen B. Calderwood, Regina C. LaRocque

129 Clostridium difficile Infection, Including Pseudomembranous ColitisDale N. Gerding, Stuart Johnson

130 Urinary Tract Infections, Pyelonephritis, and ProstatitisKalpana Gupta, Barbara W. Trautner

131 Sexually Transmitted Infections: Overview and Clinical ApproachJeanne M. Marrazzo, King K. Holmes

132 EncephalitisKaren L. Roos, Kenneth L. Tyler

133 Acute MeningitisKaren L. Roos, Kenneth L. Tyler

134 Chronic and Recurrent MeningitisWalter J. Koroshetz, Michael R. Wilson, Avindra Nath

135 Brain Abscess and EmpyemaKaren L. Roos, Kenneth L. Tyler

136 Infectious Complications of BitesSandeep S. Jubbal, Florencia Pereyra, Lawrence C. Madoff Section 3: Clinical Syndromes: Health Care-Associated Infections 137 Infections Acquired in Health Care FacilitiesRobert A. Weinstein

138 Infections in Transplant RecipientsRobert W. Finberg, Joyce D. Fingeroth Section 4: Therapy for Bacterial Diseases 139 Treatment and Prophylaxis of Bacterial InfectionsDavid C. Hooper, Erica S. Shenoy, Christy A. Varughese

140 Bacterial Resistance to Antimicrobial AgentsDavid C. Hooper Section 5: Diseases Caused by Gram-Positive Bacteria 141 Pneumococcal InfectionsDavid Goldblatt, Katherine L. O’Brien

142 Staphylococcal InfectionsFranklin D. Lowy

143 Streptococcal InfectionsMichael R. Wessels

144 Enterococcal InfectionsCesar A. Arias, Barbara E. Murray

145 Diphtheria and Other Corynebacterial InfectionsWilliam R. Bishai, John R. Murphy

146 Listeria monocytogenes InfectionsElizabeth L. Hohmann, Daniel A. Portnoy

147 TetanusC. Louise Thwaites, Lam Minh Yen

148 BotulismAgam K. Rao, Susan Maslanka

149 Gas Gangrene and Other Clostridial InfectionsAmy E. Bryant, Dennis L. Stevens Section 6: Diseases Caused by Gram-Negative Bacteria 150 Meningococcal InfectionsAndrew J. Pollard

151 Gonococcal InfectionsSanjay Ram, Peter A. Rice

152 Haemophilus and Moraxella InfectionsTimothy F. Murphy

153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative BacteriaTamar F. Barlam, Dennis L. Kasper

154 Legionella InfectionsVictor L. Yu, M. Luisa Pedro-Botet, Yusen E. Lin

155 Pertussis and Other Bordetella InfectionsKarina A. Top, Scott A. Halperin

156 Diseases Caused by Gram-Negative Enteric BacilliThomas A. Russo, James R. Johnson

157 Acinetobacter InfectionsRossana Rosa, L. Silvia Munoz-Price

158 Helicobacter pylori InfectionsJohn C. Atherton, Martin J. Blaser

159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas SpeciesReuben Ramphal

160 SalmonellosisDavid A. Pegues, Samuel I. Miller

161 ShigellosisPhilippe J. Sansonetti, Jean Bergounioux

162 Infections Due to Campylobacter and Related OrganismsBeth D. Kirkpatrick, Martin J. Blaser

163 Cholera and Other VibriosesMatthew K. Waldor, Edward T. Ryan

164 BrucellosisNicholas J. Beeching

165 TularemiaJeannine M. Petersen, Paul S. Mead

166 Plague and Other Yersinia InfectionsMichael B. Prentice

167 Bartonella Infections, Including Cat-Scratch DiseaseMichael Giladi, Moshe Ephros

168 DonovanosisNigel O’Farrell Section 7: Miscellaneous Bacterial Infections 169 NocardiosisGregory A. Filice

170 Actinomycosis Thomas A. Russo

171 Whipple’s DiseaseThomas A. Russo

172 Infections Due to Mixed Anaerobic OrganismsNeeraj K. Surana, Dennis L. Kasper Section 8: Mycobacterial Diseases 173 TuberculosisMario C. Raviglione

174 LeprosyRobert H. Gelber

175 Nontuberculous Mycobacterial InfectionsSteven M. Holland

176 Antimycobacterial AgentsDivya Reddy, Max R. O’Donnell Section 9: Spirochetal Diseases 177 SyphilisSheila A. Lukehart

178 Endemic TreponematosesSheila A. Lukehart

179 LeptospirosisJi?i F. P. Wagenaar, Marga G. A. Goris

180 Relapsing FeverAlan G. Barbour

181 Lyme BorreliosisAllen C. Steere Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae 182 Rickettsial DiseasesDavid H. Walker, J. Stephen Dumler, Lucas S. Blanton, Thomas J. Marrie

183 Infections Due to MycoplasmasR. Doug Hardy

184 Chlamydial InfectionsCharlotte A. Gaydos, Thomas C. Quinn Section 11: Viral Diseases: General Considerations 185 Medical VirologyFred Wang, Elliott Kieff

186 Antiviral Chemotherapy, Excluding Antiretroviral DrugsLindsey R. Baden Section 12: Infections Due to DNA Viruses 187 Herpes Simplex Virus InfectionsLawrence Corey

188 Varicella-Zoster Virus InfectionsRichard J. Whitley

189 Epstein-Barr Virus Infections, Including Infectious MononucleosisJeffrey I. Cohen

190 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8Camille Nelson Kotton, Martin S. Hirsch

191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus InfectionsFred Wang

192 Parvovirus InfectionsKevin E. Brown

193 Human Papillomavirus InfectionsDarron R. Brown, Aaron Ermel Section 13: Infections Due to DNA and RNA Respiratory Viruses 194 Common Viral Respiratory Infections James E. Crowe, Jr.

195 InfluenzaPeter F. Wright Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses 196 The Human RetrovirusesDan L. Longo, Anthony S. Fauci

197 Human Immunodeficiency Virus Disease: AIDS and Related DisordersAnthony S. Fauci, Gregory K. Folkers, H. Clifford Lane Section 15: Infections Due to RNA Viruses 198 Viral GastroenteritisUmesh D. Parashar, Roger I. Glass

199 Enterovirus, Parechovirus, and Reovirus InfectionsJeffrey I. Cohen

200 Measles (Rubeola)Kaitlin Rainwater-Lovett, William J. Moss

201 Rubella (German Measles)Laura A. Zimmerman, Susan E. Reef

202 MumpsSteven A. Rubin

203 Rabies and Other Rhabdovirus InfectionsAlan C. Jackson

204 Arthropod-Borne and Rodent-Borne Virus InfectionsJens H. Kuhn, Rémi N. Charrel

205 Ebolavirus and Marburgvirus InfectionsJens H. Kuhn Section 16: Fungal Infections 206 Diagnosis and Treatment of Fungal InfectionsJohn E. Edwards, Jr.

207 HistoplasmosisChadi A. Hage, L. Joseph Wheat

208 CoccidioidomycosisNeil M. Ampel

209 BlastomycosisS. Travis King, Rathel L. Nolan, III

210 CryptococcosisArturo Casadevall

211 CandidiasisJohn E. Edwards, Jr.

212 AspergillosisDavid W. Denning

213 MucormycosisBrad Spellberg, Ashraf S. Ibrahim

214 Superficial Mycoses and Less Common Systemic MycosesCarol A. Kauffman

215 Pneumocystis InfectionsAlison Morris, Henry Masur Section 17: Protozoal and Helminthic Infections: General Considerations 216 Introduction to Parasitic Infections Sharon L. Reed, Charles E. Davis

217 Agents Used to Treat Parasitic InfectionsThomas A. Moore Section 18: Protozoal Infections 218 Amebiasis and Infection with Free-Living AmebaeRosa M. Andrade, Sharon L. Reed

219 MalariaNicholas J. White, Elizabeth A. Ashley

220 BabesiosisEdouard Vannier, Peter J. Krause

221 LeishmaniasisShyam Sundar

222 Chagas Disease and African TrypanosomiasisFrançois Chappuis, Yves Jackson

223 Toxoplasma InfectionsKami Kim

224 Protozoal Intestinal Infections and TrichomoniasisPeter F. Weller Section 19: Helminthic Infections 225 Introduction to Helminthic InfectionsPeter F. Weller

226 Trichinellosis and Other Tissue Nematode InfectionsPeter F. Weller

227 Intestinal Nematode InfectionsPeter F. Weller, Thomas B. Nutman

228 Filarial and Related InfectionsThomas B. Nutman, Peter F. Weller

229 Schistosomiasis and Other Trematode InfectionsBirgitte Jyding Vennervald

230 Cestode InfectionsA. Clinton White, Jr., Peter F. Weller Part 6: Disorders of the Cardiovascular System Section 1: Introduction to Cardiovascular Disorders 231 Approach to the Patient with Possible Cardiovascular DiseaseJoseph Loscalzo

232 Basic Biology of the Cardiovascular SystemJoseph Loscalzo, Peter Libby, Calum A. MacRae

233 Epidemiology of Cardiovascular DiseaseThomas A. Gaziano, J. Michael Gaziano Section 2: Diagnosis of Cardiovascular Disorders 234 Physical Examination of the Cardiovascular SystemPatrick T. O’Gara, Joseph Loscalzo

235 ElectrocardiographyAry L. Goldberger

236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography ImagingMarcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon

237 Diagnostic Cardiac Catheterization and Coronary AngiographyJane A. Leopold, David P. Faxon Section 3: Disorders of Rhythm 238 Principles of ElectrophysiologyDavid D. Spragg, Gordon F. Tomaselli

239 The Bradyarrhythmias: Disorders of the Sinoatrial NodeDavid D. Spragg, Gordon F. Tomaselli

240 The Bradyarrhythmias: Disorders of the Atrioventricular NodeDavid D. Spragg, Gordon F. Tomaselli

241 Approach to Supraventricular TachyarrhythmiasGregory F. Michaud, William G. Stevenson

242 Physiologic and Non-physiologic Sinus Tachycardia Gregory F. Michaud, William G. Stevenson

243 Focal Atrial Tachycardia Gregory F. Michaud, William G. Stevenson

244 Paroxysmal Supraventricular TachycardiasGregory F. Michaud, William G. Stevenson

245 Common Atrial Flutter, Macroreentrant and Multifocal Atrial TachycardiasGregory F. Michaud, William G. Stevenson

246 Atrial FibrillationGregory F. Michaud, William G. Stevenson

247 Approach to Ventricular Arrhythmias Roy M. John, William G. Stevenson

248 Premature Ventricular Beats, Non-sustained Ventricular Tachycardia, and Idioventricular Rhythm Roy M. John, William G. Stevenson

249 Sustained Ventricular Tachycardia William G. Stevenson, Roy M. John

250 Polymorphic Ventricular Tachycardia and Ventricular FibrillationWilliam G. Stevenson, Roy M. John

251 Electrical Storm and Incessant VTWilliam G. Stevenson, Roy M. John Section 4: Disorders of the Heart 252 Heart Failure: Pathophysiology and DiagnosisDouglas L. Mann, Murali Chakinala

253 Heart Failure: ManagementMandeep R. Mehra

254 Cardiomyopathy and MyocarditisNeal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo

255 Cardiac Transplantation and Prolonged Assisted Circulation Mandeep R. Mehra

256 Aortic Valve ?DiseasePatrick T. O’Gara, Joseph Loscalzo

257 Aortic Regurgitation Patrick T. O’Gara, Joseph Loscalzo

258 Mitral StenosisPatrick T. O’Gara, Joseph Loscalzo

259 Mitral RegurgitationPatrick T. O’Gara, Joseph Loscalzo

260 Mitral Valve ProlapsePatrick T. O’Gara, Joseph Loscalzo

261 Tricuspid Valve DiseasePatrick T. O’Gara, Joseph Loscalzo

262 Pulmonic Valve DiseasePatrick T. O’Gara, Joseph Loscalzo

263 Multiple and Mixed Valvular Heart DiseasePatrick T. O’Gara, Joseph Loscalzo

264 Congenital Heart Disease in the AdultAnne Marie Valente, Michael J. Landzberg

265 Pericardial DiseaseEugene Braunwald

266 Atrial Myxoma and Other Cardiac TumorsEric H. Awtry Section 5: Coronary and Peripheral Vascular Disease 267 Ischemic Heart DiseaseElliott Antman, Joseph Loscalzo

268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)Robert P. Giugliano, Christopher P. Cannon, Eugene Braunwald

269 ST-Segment Elevation Myocardial InfarctionElliott M. Antman, Joseph Loscalzo

270 Percutaneous Coronary Interventions and Other Interventional ProceduresDavid P. Faxon, Deepak L. Bhatt

271 Hypertensive Vascular DiseaseTheodore A. Kotchen

272 Renovascular DiseaseStephen C. Textor

273 Deep Venous Thrombosis and Pulmonary ThromboembolismSamuel Z. Goldhaber

274 Diseases of the AortaMark A. Creager, Joseph Loscalzo

275 Arterial Diseases of the ExtremitiesMark A. Creager, Joseph Loscalzo

276 Chronic Venous Disease and Lymphedema Mark A. Creager, Joseph Loscalzo

277 Pulmonary HypertensionAaron B. Waxman, Joseph Loscalzo Part 7: Disorders of the Respiratory System Section 1: Diagnosis of Respiratory Disorders 278 Approach to the Patient with Disease of the Respiratory SystemPatricia A. Kritek, Bruce D. Levy

279 Disturbances of Respiratory FunctionEdward T. Naureckas, Julian Solway

280 Diagnostic Procedures in Respiratory DiseaseAnne L. Fuhlbrigge, Augustine M.K. Choi Section 2: Diseases of the Respiratory System 281 AsthmaPeter J. Barnes

282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with EosinophiliaPraveen Akuthota, Michael E. Wechsler

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