There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerative diseases and other ailments. Topics include:

• The basic aspects of melatonin’s physiology, including its production, bioavailability, and metabolism
• The functional importance of melatonin receptors and their role in mediating the therapeutic effectiveness of melatonin in cancer
• Melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms
• The cardioprotective role of melatonin
• The neuroprotective role in glaucoma, Alzheimer’s disease, Parkinson’s disease, and neurodegenerative diseases
• Use as a therapeutic agent for treating epilepsy and degenerative discs
• Treatment for obesity, diabetes mellitus, and other metabolic disorders
• Protective role in peri-natal hypoxic-ischemia

The contributors also examine the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders. Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the book is a significant milestone in our knowledge about advances in melatonin’s physiology and its therapeutic application in a number of disorders.

Melatonin Production and Bioavailability; Emel Oyku Cetin, Yiğit Uyanıkgil, Mehmet Turgut, and Meral Baka
Deviations of Melatonin Levels and Signaling in Aging and Diseases: Options and Limits of Treatment; Rudiger Hardeland
Pineal Gland Volume and Melatonin; Niyazi Acer, Suleyman Karademir, and Mehmet Turgut
Melatonin’s Beneficial Effects in Metabolic Syndrome with Therapeutic Applications; Venkataramanujam Srinivasan, Yoshiji Ohta, Javier Espino, Rahimah Zakaria, and Mahaneem Mohamed
Therapeutic Applications of Melatonin in Pediatrics; Emilio J. Sanchez-Barcelo, Maria D. Mediavilla, and Russel J. Reiter
Neuroprotective Effect of Melatonin on Perinatal Hypoxia–Ischemia; Daniel Alonso-Alconada, Antonia Alvarez, and Enrique Hilario
Melatonin as a Therapeutic Agent for Sepsis; Edward H. Sharman and Stephen C. Bondy
Melatonin’s Cardioprotective Role; Alberto Dominguez-Rodriguez and Pedro Abreu-Gonzalez
Melatonin: Therapeutic Value and Neuroprotection in Stroke; Max Franzblau, Nick Franzese, Gabriel S. Gonzales-Portillo,
Chiara Gonzales-Portillo, Meaghan Staples, Mia C. Borlongan, Naoki Tajiri, Yuji Kaneko, and Cesar V. Borlongan
Melatonin’s Antiapoptotic Activity in Neurodegenerative Diseases; Xin Wang, Yingjun Guan, Wenyu Fu, Shuanhu Zhou, and Zheng-Hong Qin
MT2 Melatonin Receptors: Their Role in Sleep and Neuropsychiatric Disorders; Stefano Comai and Gabriella Gobbi
Melatonin: Its Hepatoprotective Actions and the Role of Melatonin Receptors; Alexander M. Mathes
Melatonin Signaling in the Control of Plasmodium Development and Replication; Alexandre Budu and Celia R. S. Garcia
Melatonin: Regulator of Adult Hippocampal Neurogenesis; Gerardo B. Ramirez-Rodriguez and Leonardo Ortiz-Lopez
Comparison of Neuroprotective Effect of Melatonin in the Nigrostriatal and Mesolimbic Dopaminergic Systems of the Zitter Rat; Shuichi Ueda, Ayuka Ehara, Kenichi Inoue, Tomoyuki Masuda, Shin-ichi Sakakibara, and Kanji Yoshimoto
Melatonin’s Neuroprotective Role in Parkinson’s Disease; Venkataramanujam Srinivasan, Timo Partonen, Mahaneem Mohamed, Rahimah Zakaria, Asma Hayati Ahmad, Charanjit Kaur, Domenico De Berardis, Edward C. Lauterbach,
Samuel D. Shillcutt, and U.S. Srinivasan
Neuroprotective Role of Melatonin in Glaucoma; Ruth E. Rosenstein, Maria C. Moreno, Pablo Sande, Marcos Aranda,
Maria F. Gonzalez Fleitas, and Nicolas Belforte
Melatonin Receptors and Their Preventive Role in Carcinogenesis; Raffaela Santoro, Maria Ferraiuolo, Giovanni Blandino, Paola Muti, and Sabrina Strano
Enhancement of Antitumor Activity of Ursolic Acid by Melatonin in Colon Cancer Cells; Wei Guo, Jingshu Wang, and Wuguo Deng
Synthetic Melatonin Receptor Ligands; Silvia Rivara, Marco Mor, Annalida Bedini, and Gilberto Spadoni
Evaluation of Synthetic Melatonin Analog Antioxidant Compounds; Sibel Suzen
Melatonin’s Analogues in Glaucoma; Hanan Awad Alkozi and Jesus Pintor
Melatonergic Drugs as Therapeutic Agents for Insomnia and Depressive Disorders; Venkataramanujam Srinivasan, Domenico De Berardis, Amnon Brzezinski, Rahimah Zakaria, Zahiruddin Othman, Samuel D. Shillcutt, Edward C. Lauterbach, Gregory M. Brown, and Timo Partonen
Agomelatine: A Neuroprotective Agent with Clinical Utility beyond Depression and Anxiety; Cecilio Alamo, Francisco Lopez-Munoz, and Pilar Garcia-Garcia
Melatonergic Antidepressant Agomelatine in Depressive and Anxiety Disorders; Domenico De Berardis, Michele Fornaro, Venkataramanujam Srinivasan, Stefano Marini, Nicola Serroni, Daniela Campanella, Gabriella Rapini, Luigi Olivieri, Felice Iasevoli, Alessandro Valchera, Giampaolo Perna, Maria Antonia Quera-Salva, Monica Mazza, Marilde Cavuto, Ida Potena, Giovanni Martinotti, and Massimo Di Giannantonio
Effects of Melatonin and Melatonergic Drugs in Transgenic Mouse Models of Alzheimer’s Disease; Beatriz B. Otalora, M. Angeles Rol, and Juan A. Madrid
Melatonin’s Mitochondrial Protective Role in Alzheimer’s Mice: Role of Melatonin Receptors; Vedad Delic and Patrick C. Bradshaw
Melatonin and Its Therapeutic Implications in Injuries of the Developing Brain and Retina; Gurugirijha Rathnasamy, Eng-Ang Ling, and Charanjit Kaur
Melatonin’s Protection against Human Prion-Mediated Neurotoxicity; Jae-Kyo Jeong and Sang-Youel Park
Melatonin’s Protection against Methamphetamine Toxicity in Neuroblastoma Cells; Banthit Chetsawang
Melatonin’s Beneficial Effects on Dopaminergic Neurons in the Rat Model of Parkinson’s Disease; Manisha Gautam, Reshu Gupta, Ravinder Kumar Saran, and Bal Krishana
Antiepileptic Effects of Melatonin; M. Hakan Seyithanoğlu, Mehmet Turgut, Meliha Gundağ Papaker, Mustafa Ayyıldız, Suleyman Kaplan, and Saffet Tuzgen
Analgesic Effects of Melatonin; Selcuk Yavuz, Mehmet Turgut, Ozlem Yalcınkaya Yavuz, and Teoman Aydın
Effects of Melatonin on the Proliferative and Differentiative Activity of Neural Stem Cells; Saime İrkoren, Heval Selman Ozkan, and Mehmet Turgut
Role of Melatonin in Collagen Synthesis; Ozgur Taşpınar, Mehmet Turgut, Engin Taştaban, and Teoman Aydın
Melatonin Use in Peripheral Nerve Injury; Mehmet Emin Onger, Suleyman Kaplan, Ebru Elibol, Omur Gulsum Deniz,
and Berrin Zuhal Altunkaynak
Neuroprotective Role of Melatonin and Its Agonists: Neuroprotective Role of Melatonin against Dexamethasone-Induced Neurotoxicity; Aziza B. Shalby and Hanaa H. Ahmed
Does Melatonin Have a Protective Role against Side Effects of Nonsteroidal Anti-Inflammatory Drugs? Ebru Elibol, Berrin Zuhal Altunkaynak, Omur Gulsum Deniz, Mehmet Emin Onger, and Suleyman Kaplan
Melatonin: Pharmacological Aspects and Clinical Trends; Emiliano Ricardo Vasconcelos Rios
Protective Effects of Melatonin in Radiation-Induced Nephrotoxicity; Eda Kucuktulu and Uzer Kucuktulu
Melatonin and Familial Mediterranean Fever; Engin Taştaban, Mehmet Turgut, and Teoman Aydın
Effects of Melatonin on Osteoblastic and Osteoclastic Activities of Bone Tissue; Meliha Gundağ Papaker, M. Hakan Seyithanoğlu, Mehmet Turgut, Suleyman Kaplan, and Saffet Tuzgen
Phyto-Melatonin: A Novel Therapeutic Aspect of Melatonin in Nature’s Way; Chandana Haldar, Somenath Ghosh, and Amaresh Kumar Singh

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