｜저자 소개｜

Sung-Han Kim, MD. PhD, FIDSA

Department of Infectious Diseases

Asan Medical Center

Seoul, South Korea

｜책 속으로｜

For more than twenty years at the bedside, my research has begun where patient care leaves questions unanswered. Each case arrives with its own quiet provocations: Why did we miss the earliest moment to diagnose? Could a different pathway have led

to a safer, faster recovery? Over time, I came to see that research is not separate from the clinic—it is the disciplined pursuit of answers to the questions our patients give us.

This book grew out of fifteen-plus years of teaching residents and fellows how to turn those questions into studies worth doing—and papers worth writing. In morning reports, on rounds, and especially in our weekly Friday case conferences, we practiced

a simple habit: start from the case, ask many precise questions, then choose one that is answerable, impactful, and methodologically sound. Repeated often enough, that habit becomes a craft.

Part I is a practical invitation to that craft. It shows how a single case can branch into multiple researchable questions—diagnostic, therapeutic, prognostic, systemslevel—and how to narrow from curiosity to a study design that fits your time and data. The goal is motivation with traction: to help young physicians take a first step into research that improves care, not just careers.

Part II collects selected infectious-disease cases from more than fifteen years of those Friday conferences, refined into a quiz–answer–review format. The cases were chosen not for their drama but for their teachable pivots: a misweighted pretest probability, an overlooked exposure, a culture that finally clarified the picture, a treatment decision that proved decisive. Read them as you would see patients—one by one—and let each answer sharpen your clinical judgment and suggest your next study.

PART I. Medical Research Originating from Questions Patients Leave Behind: Research Sparked in the Clinic

Case 01. Unmasking the diagnostic challenge: Distinguishing IPA from TB in immunocompromised patients 

Case 02. Revealing the risk of saving lives: Nosocomial transmission of SFTS in healthcare workers 

Case 03. A diagnostic dilemma: Differentiating invasive aspergillosis from mucormycosis in immunocompromised patients 

Case 04. A silent transmission: Fatal disseminated scedosporiosis in a transplant recipient from a nearly-drowned donor 

Case 05. Invasive pulmonary aspergillosis in a patient with severe febrile thrombocytopenic syndrome 

Case 06. Persistent fever despite of antifungal therapy in a patient with chronic disseminated candidiasis 

Case 07. Enlargement of lymph node during appropriate anti-tuberculous treatment in a patient with tuberculous lymphadenopathy 

Case 08. Enlargement of lymph node after completion of anti-tuberculous treatment in a patient with tuberculous lymphadenopathy 

PART II. Case-based Learning in Infectious Diseases

Case 01. A 22-year-old male solider with fever and cough 

Case 02. A patient with fever and rash after Nepal travel 

Case 03. A 23-year-old patient with fever and altered mentality 

Case 04. A patient with high fever who live in suburban area 

Case 05. A CAR-T recipient with abnormal behavior 

Case 06. A patient with the gangrenous change in four extremities 

Case 07. A patient with liver cirrhosis who had leg swelling 

Case 08. A patient with fever and dysuria who had a history of Phillipines travle 3 months ago

Case 09. A patient with multiple joint pain who was receiving anti-TB therapy 

Case 10. A patient who developed hypoxia during daptomycin treatment 

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