Hematology and Oncology – as only Harrison’s can cover it

Featuring a superb compilation of chapters on hematology and oncology that appear in Harrison’s Principles of Internal Medicine, Eighteenth Edition, this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find content from renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation.

Features

• Organized into twelve sections: The Cellular Basis of Hematopoiesis; Cardinal Manifestations of Hematologic Diseases; Anemias, Myeloproliferative Disorders; Hematologic Malignancies; Disorders of Hemostasis; Biology of Cancer; Principles of Cancer Prevention and Treatment; Neoplastic Disorders; Endocrine Neoplasia; Remote Effects of Cancer; and Oncologic Emergencies and Late Effects Complications
• Each chapter contents relevant information on the genetics, cell biology, pathophysiology, and treatment of specific disease entities
• Chapters on hematopoiesis, cancer cell biology, and cancer prevention reflect the rapidly growing body of knowledge in these areas
• Integration of pathophysiology with clinical management
• 153 high-yield questions and answers drawn from Harrison’s Principles of Internal Medicine Self-Assessment and Board Review, 18e
• Content updates and new developments since the publication of Harrison’s Principles of Internal Medicine, 18e
• 55 chapters written by physicians who are recognized experts in the field of hematology and oncology
• Helpful appendix of laboratory values of clinical importance

Contributors

Preface

Section I The Cello Lar Basis Of Hematopoiesis

1 Hematopoietic Stem Gals 2

Section II Cardinal Manifestations Of Hematologic Disease Dan L. Longo Longo, Dan L.

2 Anemia and Polycythemia Dan L. Longo Longo, Dan L. 10

3 Bleeding and Thrombosis Dan L. Longo Longo, Dan L. 22

4 Enlargement of Lymph Nodes and Spleen Barbara A. Konkle Konkle, Barbara A. 32

5 Disorders of Granulocytes and Monocytes Dan L. Longo Longo, Dan L. 42

6 Atlas of Hematology and Analysis of Peripheral Blood Smears John I. Gain Gain, John I. 57

Section III Anemias Dan L. Longo Longo, Dan L.

7 Iron Deficiency and Other Hypoproliferative Anemias Dan L. Longo Longo, Dan L. 70

8 Disorders of Hemoglobin John W. Adamson Adamson, John W. 81

9 Megaloblastic Anemias Edward J. Benz, Jr. Benz, Edward J., Jr. 95

10 Hemolytic Anemias and Anemia Due to Acute Blood Loss A. Victor Hebrand Hebrand, A. Victor 110

11 Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes Lucio Luzzatto Luzzatto, Lucio 128

12 Transfusion Biology and Therapy Neal S. Young Young, Neal S. 143

Section IV Myeloproliferative Disorders Kenneth C. Anderson Anderson, Kenneth C.

13 Polycythemia Vera and Other Myeloproliferative Diseases Kenneth C. Anderson Anderson, Kenneth C. 154

Section V Hematologic Malignancies Jerry L. Spivak Spivak, Jerry L.

14 Acute and Chronic Myeloid Leukemia. Jerry L. Spivak Spivak, Jerry L. 166

15 Malignancies of Lymphoid Cells Clara D. Bloomfield Bloomfield, Clara D. 182

16 Plasma Cell Disorders Dan L. Longo Longo, Dan L. 205

17 Amyloidosis Kenneth C. Anderson Anderson, Kenneth C. 217

Section VI Disorders Of Hemostasis Martha Skinner Skinner, Martha

18 Disorders of Platelets and Vessel Wall Martha Skinner Skinner, Martha 224

19 Coagulation Disorders Barbara A. Konkle Konkle, Barbara A. 235

20 Venous Thrombosis Katherine A. High High, Katherine A. 246

21 Pulmonary Thromboembolism H.R. Bailer Bailer, H. R. 253

22 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs Samuel Z. Goldhaber Goldhaber, Samuel Z. 264

Section VII Biology Of Cancer Jeffrey I. Weitz Weitz, Jeffrey I.

23 Cancer Genetics Jeffrey I. Weitz Weitz, Jeffrey I. 284

24 Cancer Cell Biology and A ngiogenesis Bert Vogelstein Vogelstein, Bert 294

Section VIII Principles Of Cancer Prevention And Treatment Dan L. Longo Longo, Dan L.

25 Approach to the Patient with Cancer Dan L. Longo Longo, Dan L. 320

26 Prevention and Early Detection of Cancer Dan L. Longo Longo, Dan L. 332

27 Principles of Cancer Treatment Barnett S. Kramer Kramer, Barnett S. 343

28 Infections in Patients with Cancer Dan L. Longo Longo, Dan L. 374

29 Hematopoietic Cell Transplantation Robert Finberg Finberg, Robert 388

30 Palliative and End-of-Life Care Frederick R. Appelbaum Appelbaum, Frederick R. 398

Section IX Neoplastic Disorders Linda L. Emanuel Emanuel, Linda L.

31 Cancer of the Skin Linda L. Emanuel Emanuel, Linda L. 422

32 Head and Neck Cancer Carl V. Washington, Jr. Washington, Carl V., Jr. 433

33 Neoplasms of the Lung Everett E. Vokes Vokes, Everett E. 439

34 Breast Cancer Joan H. Schiller Schiller, Joan H. 459

35 Gastrointestinal Tract Cancer Marc E. Lippman Lippman, Marc E. 472

36 Tumors of the Liver and Biliary Tree Robert J. Mayer Mayer, Robert J. 489

37 Pancreatic Cancer Brian I. Carr Carr, Brian I. 499

38 Bladder and Renal Cell Carcinomas avid Cunningham Cunningham, avid 504

39 Benign and Malignant Diseases of the Prostate. Robert J. Motzer Motzer, Robert J. 511

40 Testicular Cancer Howard I. Scher Scher, Howard I. 524

41 Gynecologic Malignancies George J. Bosl Bosl, George J. 530

42 Soft Tissue and Bone Sarcomas and Bone Metastases Robert C. Young Young, Robert C. 540

43 Primary and Metastatic Tumors of the Nervous System Robert S. Benjamin Benjamin, Robert S. 547

44 Carcinoma of Unknown Primary Mark A. Israel Israel, Mark A. 562

Section X Endocrine Neoplasia James L. Abbruzzese Abbruzzese, James L.

45 Thyroid Cancer James L. Abbruzzese Abbruzzese, James L. 570

46 Endocrine Tumors of the Gastrointestinal Tract and Pancreas Anthony P. Weetman Weetman, Anthony P. 578

47 Multiple Endocrine Neoplasia Robert T. Jensen Jensen, Robert T. 597

48 Pheochromocytoma and Adrenocortical Carcinoma Robert P Gagel Gagel, Robert P 609

Section XI Remote Effects Of Cancer Dan L. Longo Longo, Dan L.

49 Paraneoplastic Syndromes: Endocrinologic/Hematologic Dan L. Longo Longo, Dan L. 622

50 Paraneoplastic Neurologic Syndromes Bruce E. Johnson Johnson, Bruce E. 631

Section XII Oncologic Emergencies And Late Complications Myrna R. Rosenfeld Rosenfeld, Myrna R.

51 Oncologic Emergencies Myrna R. Rosenfeld Rosenfeld, Myrna R. 642

52 Late Consequences of Cancer and Its Treatment Janice P. Dutcher Dutcher, Janice P. 657

Appendix Laboratory Values of Clinical Importance Dan L. Longo Longo, Dan L. 663

Review and Self-Assessment Daniel J. Fink Fink, Daniel J. 685

Index Adam Spivak Spivak, Adam 731