This latest edition continues the tradition of excellence of previous editions with comprehensive, authoritative coverage of rheumatic disease from basic scientific principles to practical points of clinical management. Internationally renowned authors deliver essential information on the definition of a disease, epidemiology, pathophysiology, clinical findings, differential diagnosis, and disease management. A consistent style and lavishly illustrated full-color format presents you with comprehensive clinical and scientific information in a lucid, logical, user-friendly manner. A must have for all practitioners in the field!

Section 1: The Scientific Basis of Rheumatic Disease *Epidemiologic Concepts and Classification of Rheumatology *Principles of Outcome Assessment *The Worldwide Economic and Functional Impact of *Rheumatic Disorders and Pharmaconomics *Principles of Health Economics and Application to Rheumatic Disorders and Pharmaconomics *The Musculoskeletal System and Joint Physiology *Anatomy and Biomechanics of the Spine *Biomechanics of Peripheral Joints *The Synovium Articular cartilage *Bone Structure and Function *Molecular Biology Signal Transduction *Genetic Factors in rheumatic disease *Principles of adaptive immunity Principles of Innate Immunity *Tissue Destruction and Repair *Neuropeptides, Free Radicals and Inflammation Scientific Basis of Pain Pharmacogenomics Section 2: Evaluation: Signs and Symptoms *History and Physical Examination *Pattern Recognition Arthritis *Laboratory Tests in Rheumatic Disorders *Synovial Fluid Analysis *Minimally Invasive Procedures *Skin and Rheumatic Disease *The Eye and Rheumatic disease *The Heart in Rheumatic Disease *The Lung in Rheumatic Disease *Gastrointestinal Tract and Rheumatic Disease *The Kidney and Rheumatic Diseases Section 3: Evaluation Imaging Techniques Conventional Radiography and CT MRI Ultrasound *DXA and Measurement of Bone Section 4: Principles of Management *Health Promotion and Patient Education for People with Arthritis Nutrition *Principles of Opiate Management *NSAIDS *Systemic Corticosterioids in Rheumatology *Aspiration and Injection of Joints *Antimalarials and Gold *Sulfasalazine *Methotrexate Leflunomide *Immunosuppressives *Immunotherapies: T cell, B cell cCmplement Other drugs in Rheumatic Disease Cytokine neutralizers: IL1 inhibitors *Cytokine Neutralizers: TNF alpha *Emerging Therapeutic Targets; Small Molecules Emerging Therapeutic Targets; IL6, IL15, IL18, IL23, etc *Antibiotics *Drugs and Pregnancy *Alternative and Complementary Medicine *Principles of Rehabilitiation *Principles of Arthritis Surgery Section 5: Regional and Widespread Pain *Neck Pain *Low Back Pain and Lumbar Spinal Stenosis *The Shoulder *The Elbow *The Wrist and Hand *The Hip *The Knee *The Ankle *Temporomandibular Pain Syndrome *Fibromyalgia and related Syndromes *Entrapment neuropathies and Compartment Syndromes *Algodystrophy/reflex Sympathetic Dystrophy Syndrome *Sports Medicine: the Clinical Spectrum of Injury Section 6: Rheumatoid Arthritis and Other Synovial Disorders *Antiquity of RA *Classification of RA *Extra-articular Features of RA and Systemic Involvement *Adult Stills Disease *Imaging of RA *Genetics of the Major Histocompatiablity Complex in RA *Animal models of RA *Autoantibodies in RA *Cellular immunity in RA *Angiogenesis in RA *Rheumatoid Synovitis and Pannus *Evaluation and Management of Early Inflammatory Polyarthritis *Evaluation and Outcome of the Patient with Established RA *Management of RA: synovitis *Management of Extra-articular disease and Complications *Multidisciplinary Approach to RA Section 7: Pediatric Rheumatology *History of Pediatric Rheumatology *Classification and Epidemiology of Juvenile Inflammatory Arthritis *Clinical Features, Special problems and Presentations in Children *Etiology and Pathogenesis of JRA *Evaluation of Musculoskeletal Complaints in Children *Management of Juvenile Idiopathic Arthritis *Connective Tissue Diseases in Children *Legg-Perthes and other Hip Disease in Children *Rehabilitation and Psychosocial Issues Section 8: Infection-related rheumatic diseases *Septic Arthritis, Osteomyelitis, Gonococcal and Syphilitic Arthritis *Mycobacterial, Brucella, Fungal and Parasitic Arthritis *Lyme Disease *Viral Arthritis *Rheumatic Aspects of HIV Infection and other Immunodeficient States *Acute Rheumatic Fever Reactive Arthritis: Etiology and Pathogenesis Reactive Arthritis: Clinical Features and Treatment Section 9: Spondyloarthropathies *Antiquity of Spondyloarthropathies *Classification and Epidemiology of Spondylitis *Clinical features of Ankylosing Spondylitis Etiology, Pathogenesis and Pathology of Ankylosing Spondylitis *Seronegative Spondyloarthropathies: Imaging *Management of Ankylosing Spondylitis *Psoriatic Arthritis: Clinical Feature *Psoriatic Arthritis Etiology and Pathogenesis *Psoriatic Arthritis: Management *Enteropathic Arthropathies: Diagnosis and Treatment *Enthesopathy Section 10: Connective Tissues Disorders Systemic Lupus Erythematosus *History *Epidemiology and classification *Immunopathology *Genetics of Lupus *The Complement System *Autoantibodies in SLE *Cellular immunology in SLE *Clinical features of SLE *Drug-induced Lupus *Assessing Disease Activity and Outcome in SLE *Treatment of Non-Renal Lupus *Treatment ? Renal Involvement Pregnancy in SLE and Neonatal Lupus *Sjogrens syndrome *Antiphospholipid Syndrome: Diagnosis and Management Systemic Sclerosis *Epidemiology and Classification of Scleroderma *Assessing Disease activity and outcome in scleroderma *Clinical features of scleroderma *Etiology and pathogenesis of systemic sclerosis *Management of scleroderma *Raynaud`s Phenomenon *Localized Scleroderma and Idiopathic and *Environmentally Induced Scleroderma Variants Inflammatory Muscle Disease *Clinical Features, Classification and Epidemiology of Inflammatory Disease *Etiology and Pathogenesis of Inflammatory Disease *Management of Inflammatory Muscle Disease *Metabolic and Drug Induced Myopathies *Overlap Syndromes Section 11: The Vasculitides *Classification and Epidemiology of Inflammatory Vascular Diseases Biology and Immunopathogenesis of Vasculitis *Polyarteritis Nodosa and Microscopic Polyangiitis *Polymyalgia Rheumatica and Giant Cell Arteritis *Wegener`s Granulomatosis and Lymphamatoid Granulomatosis *Churg-Strauss syndrome *Takayasu`s arteritis *Behcet`s syndrome *Kawasaki Disease *Henoch-Shonlein Purpura *Panniculitis and Cutaneous Vasculitis *Cryoglobulinemia and Franklin Syndrome *Primary Angiitis of the CNS SECTION 12: Other Systemic Illnesses *Cogan`s syndrome *Sarcoidosis *Relapsing Polychondritis *Miscellaneous Arthropathies including Synovial tumors and Foreign Body Synovitis *The Amyloidoses *Clubbing and Hypertrophic Osteoarthropathy SECTION 13: Osteoarthritis and Related Disorders *Epidemiology and Classification of OA *Clinical features of OA *Osteoarthritis: Pathology and Pathogenesis *Genetics of Osteoarthritis *Imaging of OA *Evaluation of the Patient with OA and Measurement of Outcomes *Management of Limb Osteoarthritis *Diffuse Idiopathic Skeletal Hyperstosis *Neuropathic Arthropathy *Osteonecrosis Rare OA: Ochronosis, Kashanbeck, Castleman`s Disease Section 14: Crystal-related arthropathies *Epidemiology, Classification and History of Crystal-related Arthropathies *Etiology and Pathogenesis of Gout *Clinical Features of Gout *The Management of Gout *Calcium Pyrophosphate Dihydrate Crystal-Associated Arthropathy *Basic Calcium Phosphate Crystal Deposition Disease *Other Crystal Associated Arthropathies Section 15: Endocrine and Hemoglobin-related Arthritis and Storage Diseases Rheumatoid Manifestations of Endocrine Disease *Dialysis Arthropathy *Primary Hyperlipidemias and Xanthomas *Hemophilia and other Bleeding Disorders *Joint and Bone Lesions in Hemoglobinopathies *Hemochromatosis Section 16 Metabolic Bone Diseases *Epidemiology, Classification and History of Osteoporosis *Clinical Features of Osteoporosis *Pathogeneis of Osteoporosis *Investigations of Bone: biochemical markers *Management of Osteoporosis *Glucocorticoid-induced osteoporosis *Rickets and Osteomalacia *Hyperparathryoidsm *Renal osteodystrophy *Paget`s Disease of Bone Section 17: Heritable disease and tumors of bone and connective tissue *Gaucher`s Disease *Mucopolysaccharidoses *Heritable Collagen Disorders *Hypermobility Syndrome *Skeletal Dysplasias *Tumors of Bone

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