Now completely revised and updated, this comprehensive text covers all aspects of caring for the critically ill child. The clear, logical organ-system approach addresses development, function, disease, and treatment for each entity, and relates normal function, pathophysiology, and treatment to clinical problems. New chapters cover hemodynamic principles, diagnostic and therapeutic cardiac catheterization, congenital malformations of brain and spinal chord, gastrointestinal pharmacology, and a new section considers failure of organ systems.
Reviews
“The Trauma and Burns section is the best pediatric trauma reference I have encountered in any text” —Critical Care Medicine
“A text that has become the standard in most pediatric ICUs.”—JAMA
Features
• Completely revised by dozens of new contributors. • Contains new chapters covering hemodynamic principles; diagnostic and therapeutic cardiac catheterization; congenital malformations of brain and spinal cord; gastrointestinal pharmacology; and a new section on Failure of Organ Systems. • Provides a more detailed and complete understanding of the scientific basis of critical care. • Delivers significantly updated chapters on critical care in developing countries; hematology and oncology problems in the ICU; gastrointestinal pharmacology; drug interactions and adverse drug effects; and much more.
What`s New
Completely revised by dozens of new contributors.
Contains new chapters covering hemodynamic principles; diagnostic and therapeutic cardiac catheterization; congenital malformations of brain and spinal cord; gastrointestinal pharmacology; and a new section on Failure of Organ Systems.
Provides a more detailed and complete understanding of the scientific basis of critical care.
Delivers significantly updated chapters on critical care in developing countries; hematology and oncology problems in the ICU; gastrointestinal pharmacology; drug interactions and adverse drug effects; and much more.

I. The Discipline 1. Multidisciplinary Care and the Role of the Pediatric Subspecialist in the PICU 2. History of Pediatric Intensive Care 3. Pediatric Critical Care and the Intensivist in the New Hospital Environment 4. The Nurse in Pediatric Critical Care 5. Research in Pediatric Critical Care 6. Proving the Point: Evidence-based medicine in pediatric critical care 7. Outcome Prediction in Pediatric Critical Care 8. Safety and Quality Assessment in the PICU 9. Information Technology in Critical Care 10. Family Centered Care in the PICU 11. Ethics in Pediatric Intensive Care 12. Death and Dying 13. Organ Procurement and Donation 14. Pediatric Transport 15. Pediatric Vascular Access and Centeses 16. Critical Care in Developing Countries Section: II. Organ System Function and Failure: Circulation 17. Structure and Function of the Heart and Vasculature 18. Regional Circulation 19. Principles of Invasive Monitoring 20. Assessment of Cardiovascular Function 21. Echocardiography and Noninvasive Cardiac Diagnostics 22. Diagnostic and Therapeutic Cardiac Catheterization 23. Pharmacology of the Cardiovascular System 24. Cardiopulmonary Interactions 25. Myocardial Dysfunction, Ventricular Assist Devices and Extracorporeal Membrane Oxygenation 26. Cardiac Rhythm Disturbances 27. Shock States 28. Infection of the Heart and Pericardium 29. Cardiac Bypass for Repair of Congenital Heart Disease in Infants and Children 30. Critical Care After Surgery for Congenital Cardiac Disease 31. Cardiac Transplantation Section: II. Organ System Function and Failure: Respiration 32. Structure of the Respiratory System 33. Airway Management (including new airway access techniques) 34. Physiology of the Respiratory System 35. Control of Breathing and Acute Respiratory Failure 36. Assessment and Monitoring of Respiratory Function 37. Ventilation Perfusion Mismatch 38. Mechanical Function and Dysfunction of the Respiratory System 39. Noninvasive Monitoring 40. Upper Airway Disease 41. Asthma (alternately: Lower Airway Disease or Reactive Airway Disease 42. Neonatal Respiratory Disease 43. Pneumonitis and Interstitial Disease 44. Diseases of Pulmonary Circulation 45. Mechanical Ventilation and Respiratory Care 46. Ventilator Induced Lung Injury 47. Acute Respiratory Distress Syndrome 48. Extracorporeal Membrane Oxygenation Section: II. Organ System Function and Failure: CNS and Neuromuscular 49. Development, Structure, and Function of the Brain and Neuromuscular Systems 50. Neuroimaging 51. Neurological Assessment and Monitoring 52. Congenital Malformations of Brain and Spinal Cord 53. Intracranial Hypertension 54. Neurosurgical Intensive Care 55. Coma and Depressed Sensorium 56. Status Epilepticus 57. Acute Neuromuscular Diseases and Disorders in Pediatric Critical Care 58. Acute Central Nervous System Infections 59. Hypoxic Ischemic Encephalopathy: Pathobiology and Therapy of the Post-Resuscitation Syndrome in Children Section: II. Organ System Function and Failure: Renal 60. Renal Structure and Function 61. Electrolyte Management in Pediatric Critical Illness 62. Acid-Base Balance and Disorders 63. Tests of Renal Function 64. Renal Pharmacology 65. Glomerulotubular Dysfunction and Acute Renal Failure 66. Renal Replacement Therapy Section: II. Organ System Function and Failure: Metabolism and Endocrine 67. Hypertension in the PICU 68. Cellular Bioenergetic Pathways and Processes 69. Nutrient Metabolism and the Systemic Stress Response 70. Inborn Errors of Metabolism and Critical Illness 71. Disorders of the Endocrine System and Pediatric Critical Illness 72. Diabetic Ketoacidosis Section: II. Organ System Function and Failure: Hematology 73. Structure and Function of Hematopoietic Organs 74. Hematology and Oncology Problems in the Intensive Care Unit 75. Transfusion Medicine 76. Stem Cell Transplantation 77. Hemaglobinopathies Section: II. Organ System Function and Failure: Gastroenterology 78. Gastrointestinal Structure and Function 79. Disorders and Diseases of the Gastrointestinal Tract 80. Gastrointestinal Pharmacology 81. Acute Liver Failure, Liver Transplantation, and Extracorporeal Liver Support 82. Acute Abdomen Section: II. Organ System Function and Failure: Immunity and Infection 83. The Innate Immune System 84. Infection and the Host Response 85. Congenital Immunodeficiency 86. Acquired Immune Dysfunction 87. Bacterial Infection, Antimicrobial Use and Resistant Organisms in the PICU 88. Life-Threatening Viral Disease and Its Treatment 89. Infectious Syndromes in the PICU 90. Nosocomial Infection in the PICU: Epidemiology and control 91. Autoimmune Diseases and Their Treatment 92. Individuality, Gene Array Analysis and Critical Care Section: II. Organ System Function and Failure: Failure of Organ Systems 93. Molecular Foundations of Cellular Injury, Apoptosis and Necrosis 94. Endotheliopathy 95. Neuroendocrine-Inflammatory Mediator Coordination and Disarray 96. Sepsis and Septic Shock 97. Unified Concept of MODS, SIRS and ALI Section: III. Environmental Hazards 98. Principles of Toxin Screening, Assessment and Detoxification 99. Toxidromes and Their Treatment 100. Envenomation 101. Heat Injury 102. Cold Injury 103. Near Drowning 104. Burn and Inhalation Injuries Section: IV. Trauma 105. Evaluation, Stabilization and Initial Management After Multiple Trauma 106. Child Abuse and Neglect (Syndromes, social, legal and treatment) 107. Head Trauma 108. Thoracic Injuries in Children 109. Abdominal Trauma in Pediatric Critical Care V. Pharmacology 110. Principles of Drug Disposition in the Critically Ill Child 111. Molecular Aspects of Drug Actions: from Receptors to Effectors 112. Drug-Drug Interactions and Adverse Drug Effects VI. Anesthesia and Analgesia Aspects of Pediatric Critical Care 113. Organ System Considerations that Affect Anesthetic Management 114. Anesthetic Principles and Operating Room Anesthesia Regimens (include post anesthesia recovery) 115. Neuromuscular Blocking Agents 116. Sedation and Analgesia 117. Malignant Hyperthermia VII. Cardiopulmonary Resuscitation 118. Physiologic Foundations of Cardiopulmonary Resuscitation 119. Performance of CPR in Infants and Children

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