An ideal resource for both pediatricians and endocrinologists, Sperling`s Pediatric Endocrinology, 5th Edition, brings you fully up to date with accelerating research; new discoveries in metabolic, biochemical and molecular mechanisms; and the resulting advances in today`s clinical care. The editorial team of world-renowned pediatric endocrinologists led by Dr. Mark Sperling, as well as expert contributing authors, cover comprehensive and current aspects of both basic science and clinical practice. Whether you`re preparing for certification or have extensive clinical experience, this detailed, authoritative reference helps you increase your knowledge and determine the best possible course for every patient.

Key Features

Delivers trusted guidance in every area of the field: including Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests.

Features new topics such as transgender issues in children and adolescents and endocrinology of pregnancy, the fetus and the placenta.

Offers expert coverage of hot topics such as disorders of sexual development, molecular basis of endocrine disorders, hypoglycemia in newborns and infants; neonatal and other monogenic forms of diabetes; Type I and Type II diabetes and their treatment with new insulins together with the progress in an artificial pancreas and new medications for T2DM in adolescents; the obesity epidemic and role of bariatric surgery; and advances toward personalized medicine.

Includes easy-to-follow algorithms and numerous quick-reference tables and boxes in every clinical chapter, plus interactive questions online for self-assessment.

Offers state-of-the-art information and fresh perspectives from new and award-winning authors in such areas as disorders of growth, multiple endocrine tumors, and puberty and its disorders in girls and boys.

Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

SECTION I Principles and Methods of Pediatric Endocrinology, 1

1. Overview and Principles of Pediatric Endocrinology, 1

Mark A. Sperling

2. Molecular Endocrinology, Endocrine Genetics, and Precision Medicine, 9

Ram K. Menon, Massimo Trucco, Joseph A. Majzoub, Constantine A. Stratakis

3. Receptor Transduction Pathways Mediating Hormone Action,   30

Bassil Kublaoui, Michael A. Levine

4. Endocrinology Laboratory Testing, 86

Jon Nakamoto

SECTION II Endocrine Disorders in the Neonate, 106

5. Fetal-Maternal Endocrinology and Parturition, 106

Sam Mesiano, Helen N. Jones, Heide Aungst, Tani Malhotra, Louis J. Muglia

6. Ambiguous Genitalia, 123

Selma Feldman Witchel, Peter A. Lee

7. Hypoglycemia in the Newborn and Infant, 175

Diva D. De Leon, Paul Thornton, Charles A. Stanley, Mark A. Sperling

8. Disorders of the Thyroid in the Newborn and Infant,   202

Johnny Deladoey, Julia Elisabeth von Oettingen, Guy Van Vliet

9. Disorders of Mineral Metabolism: Normal Homeostasis, 220

Allen W. Root

10. Monogenic Diabetes Mellitus: Neonatal Diabetes and Maturity-Onset Diabetes of the Young, 279

Siri Atma W. Greeley*, Mary K. McCauley*, Louis H. Philipson, Mark A. Sperling

*Authors contributed equally to this chapter

SECTION III Childhood and Adolescent Endocrinology, 299

11. Disorders of Childhood Growth, 299

Alexander A.L. Jorge, Adda Grimberg, Mehul T. Dattani, Jeffrey Baron

12. Disorders of the Posterior Pituitary, 357

Abhinash Srivatsa, Joseph A. Majzoub

13. Thyroid Disorders in Children and Adolescents, 395

Scott Rivkees, Andrew J. Bauer

14. The Adrenal Cortex and Its Disorders, 425

Walter L. Miller, Christa E. Flück, David T. Breault, Brian J. Feldman

15. Pheochromocytoma/Paraganglioma, Medullary Thyroid Carcinoma, and Hereditary Endocrine Neoplasia Syndromes,    491

Steven G. Waguespack, Lauren Fishbein

16. Puberty in the Female and Its Disorders, 528

Robert L. Rosenfield, David W. Cooke, Sally Radovick

17. Turner Syndrome, 627

Philippe Backeljauw, Steven D. Chernausek, Claus Højbjerg Gravholt, Paul Kruszka

18. Puberty and Its Disorders in the Male, 661

Mark R. Palmert, Yee-Ming Chan, Leo Dunkel

19. Care of Transgender/Gender Nonconforming Youth,   695

Stephen M. Rosenthal, Amy B. Wisniewski

20. Disorders of Mineral Metabolism II. Abnormalities of Mineral Homeostasis in the Newborn, Infant, Child, and Adolescent,   705

Allen W. Root, Michael A. Levine

21. Diabetes Mellitus, 814

Mark A. Sperling, Joseph I. Wolfsdorf, Ram K. Menon, William V. Tamborlane, David Maahs, Tadej Battelino, Moshe Phillip

22. Autoimmune Polyglandular Syndromes, 884

Bimota Nambam, Michael J. Haller, William E. Winter, Desmond Schatz

23. Hypoglycemia in the Toddler and Child,    904

Joseph I. Wolfsdorf, Charles A. Stanley

24. Obesity, Metabolic Syndrome and Disorders of Energy Balance, 939

Joan C. Han, Ram Weiss

25. Lipid Disorders in Children and Adolescents, 1004

Stephen R. Daniels, Sarah C. Couch

Index, 1022

Interactive questions for self-assessment can be found in the e-book; see inside front cover for details.

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